| Rank | Student | School | Years | | TB | AB | SLUG |
| 1 | Paige Eddington | Doniphan | 2014-2017 | | 484 | 369 | 1.312 |
| 2 | Adrienne Compton | Hancock | 2012-2015 | | 264 | 202 | 1.307 |
| 3 | Ali Raley | Pierce City | 2014-2017 | | 355 | 301 | 1.179 |
| 4 | Addison Purvis | Sullivan | 2016-2019 | | 380 | 336 | 1.131 |
| 5 | Madison Marie Uptegrove | Father Tolton Regional Catholic | 2020-2023 | | 452 | 400 | 1.130 |
| 6 | Nicole Hudson | Webb City | 2005-2008 | | 372 | 331 | 1.124 |
| 7 | Maleigh Elizabeth Lemings | Holcomb | 2020-2023 | | 425 | 383 | 1.110 |
| 8 | Madison Norman | Tipton | 2010-2013 | | 241 | 224 | 1.076 |
| 9 | Abigail King | Christian | 2014-2017 | | 266 | 250 | 1.064 |
| 10 | Zoe Brittan | Valley Park | 2004-2006 | | 238 | 227 | 1.048 |
| 11 | Ashley Ellis | Fox | 2012-2015 | | 310 | 296 | 1.047 |
| 12 | Maris Ollison | Versailles | 2018-2021 | | 318 | 307 | 1.036 |
| 13 | Valerie Teter | Bevier | 2003-2006 | | 286 | 277 | 1.032 |
| 14 | Sammey Clara Bunch | Fatima | 2012-2015 | | 345 | 347 | 0.994 |
| 15 | Micah Elizabeth Scharff | Ladue Horton Watkins | 2007-2010 | | 231 | 233 | 0.991 |
| 16 | Tabitha Francka | Marion C. Early | 2012-2015 | | 275 | 298 | 0.923 |
| 17 | Hannah Marie Cox | Sullivan | 2016-2019 | | 342 | 377 | 0.907 |
| 18 | Hailey Presley | Marion C. Early | 2020-2023 | | 337 | 389 | 0.866 |
| 19 | Karsyn Brooke | Mansfield | 2015-2018 | | 322 | 383 | 0.841 |