| Rank | Student | School | Years | | G | RBI |
| 1 | Maleigh Elizabeth Lemings | Holcomb | 2020-2023 | | 127 | 256 |
| 2 | Madison McKinney | Norborne | 2012-2015 | | 96 | 220 |
| 3 | Reese Dobbins | Neelyville | 2021-2024 | | 125 | 205 |
| 4 | Paige Eddington | Doniphan | 2014-2017 | | 134 | 200 |
| 5 | Hadley Wilson | Kennett | 2020-2023 | | 123 | 199 |
| 6 | Madison Marie Uptegrove | Father Tolton Regional Catholic | 2020-2023 | | 131 | 192 |
| 7 | Cheyenne Bieber | Mt. Vernon | 2021-2024 | | 138 | 189 |
| 8 | Sydney McKinney | Norborne | 2014-2017 | | 98 | 180 |
| 9 | Mac Lane Morgan | Sherwood | 2017-2020 | | 100 | 177 |
| 10 | Katlyn Kasubke | St. Dominic | 2011-2014 | | 110 | 173 |
| 10 | Katie Wood | Norborne | 2013-2016 | | 94 | 173 |
| 12 | Ali Raley | Pierce City | 2014-2017 | | 100 | 171 |
| 13 | Hannah Marie Cox | Sullivan | 2016-2019 | | 118 | 170 |
| 13 | Hailey Presley | Marion C. Early | 2020-2023 | | 123 | 170 |
| 15 | Addie Lynn Morris | Rock Bridge | 2021-2024 | | 151 | 169 |
| 16 | Criswell, Hannah | Kennett | 2013-2016 | | 102 | 163 |
| 16 | Addison Purvis | Sullivan | 2016-2019 | | 117 | 163 |
| 18 | Nicole Hudson | Webb City | 2005-2008 | | 117 | 161 |
| 18 | Morgan Hull | Mt. Vernon | 2013-2016 | | 111 | 161 |
| 20 | Karsyn Brooke | Mansfield | 2015-2018 | | 132 | 160 |
| 21 | Kayla Patricia Ulrich | Sullivan | 2019-2022 | | 132 | 153 |
| 22 | Abby Carol Hay | Rock Bridge | 2019-2022 | | 139 | 152 |
| 23 | Sierra Culver | Kearney | 2016-2019 | | 112 | 145 |
| 24 | Elizabeth Dains | Valley Park | 2002-2005 | | 85 | 142 |
| 24 | Ashley Ellis | Fox | 2012-2015 | | 113 | 142 |
| 24 | Kylie Marie Helm | McDonald County | 2015-2018 | | 112 | 142 |
| 27 | Madison Norman | Tipton | 2010-2013 | | 82 | 140 |
| 27 | Sophia Gentry | Bishop LeBlond | 2010-2013 | | 111 | 140 |
| 27 | Shelby Ann-Renee Webster | Camdenton | 2015-2018 | | 102 | 140 |
| 30 | Brianna Isabelle Lore | Sullivan | 2008-2011 | | 103 | 139 |
| 30 | Marissa Peek | Holt | 2016-2019 | | 117 | 139 |
| 32 | Emma Nichols | Hillsboro | 2015-2018 | | 117 | 138 |
| 32 | Maci Moore | Trenton | 2018-2021 | | 106 | 138 |
| 34 | Kali Nelson | Dixon | 2012-2015 | | 98 | 136 |
| 34 | Hanna Nicole Johanning | Sullivan | 2017-2020 | | 117 | 136 |
| 36 | Valerie Teter | Bevier | 2003-2006 | | 99 | 133 |
| 37 | Adrienne Compton | Hancock | 2012-2015 | | 70 | 130 |
| 37 | Kinlei Boley | Chillicothe | 2019-2022 | | 104 | 130 |
| 39 | Salem Croy | Trenton | 2015-2018 | | 109 | 128 |
| 40 | Halle Gooch | Clearwater | 2014-2017 | | 93 | 124 |
| 41 | Keira Chrisco | Rolla | 2018-2021 | | 116 | 123 |
| 42 | Abigail King | Christian | 2014-2017 | | 84 | 121 |
| 42 | Brooke Huitt | Lathrop | 2015-2018 | | 112 | 121 |
| 44 | Audrey Carlton | Ozark | 2021-2024 | | 139 | 116 |
| 45 | Makenzie Marie Gladney | Elsberry | 2019-2022 | | 95 | 85 |