| Rank | Student | School | Years | | HR | G | AVG |
| 1 | Kylie Walker | Senath-Hornersville | 2021-2022 | | 21 | 32 | 0.656 |
| 2 | Mac Lane Morgan | Sherwood | 2017-2020 | | 47 | 100 | 0.470 |
| 3 | Anastasia Grace Mueller | Pacific | 2016-2019 | | 41 | 96 | 0.427 |
| 4 | Taylor Hamilton | Cameron | 2011-2014 | | 41 | 104 | 0.394 |
| 5 | Katie Ann Chester | Liberty North | 2018-2021 | | 42 | 114 | 0.368 |
| 5 | Katie Ann Chester | Liberty North | 2018-2021 | | 42 | 114 | 0.368 |
| 7 | Madison Marie Uptegrove | Father Tolton Regional Catholic | 2020-2023 | | 48 | 131 | 0.366 |
| 8 | Abby Carol Hay | Rock Bridge | 2022-2023 | | 43 | 122 | 0.352 |
| 9 | Kara Kaye Daly | Jefferson City | 2017-2020 | | 36 | 104 | 0.346 |
| 10 | Valerie Teter | Bevier | 2003-2006 | | 34 | 99 | 0.343 |
| 11 | Nicole Hudson | Webb City | 2005-2008 | | 40 | 117 | 0.342 |
| 12 | Adrienne Compton | Hancock | 2012-2015 | | 23 | 70 | 0.329 |
| 13 | Paige Eddington | Doniphan | 2014-2017 | | 43 | 134 | 0.321 |
| 14 | Carlie Sanders | Hillsboro | 2014-2017 | | 34 | 107 | 0.318 |
| 15 | Jessica Damico | Pacific | 2007-2010 | | 29 | 94 | 0.309 |
| 16 | Addison Purvis | Sullivan | 2016-2019 | | 36 | 117 | 0.308 |
| 17 | Hannah Marie Cox | Sullivan | 2016-2019 | | 36 | 118 | 0.305 |
| 18 | Ashley Ellis | Fox | 2012-2015 | | 34 | 113 | 0.301 |
| 19 | Erin McPike | East Buchanan | 2017-2020 | | 27 | 91 | 0.297 |
| 19 | Erin McPike | East Buchanan | 2017-2020 | | 27 | 91 | 0.297 |
| 21 | Jordan Shewmaker | Buffalo | 2010-2013 | | 29 | 98 | 0.296 |
| 22 | Shelby Ann-Renee Webster | Camdenton | 2015-2018 | | 30 | 102 | 0.294 |
| 22 | Shelby Ann-Renee Webster | Camdenton | 2015-2018 | | 30 | 102 | 0.294 |
| 24 | Sierra Culver | Kearney | 2016-2019 | | 31 | 112 | 0.277 |
| 25 | Maleigh Elizabeth Lemings | Holcomb | 2020-2023 | | 35 | 127 | 0.276 |
| 26 | Maci Moore | Trenton | 2018-2021 | | 29 | 106 | 0.274 |
| 27 | Maris Ollison | Versailles | 2018-2021 | | 28 | 103 | 0.272 |
| 28 | Cindy Wolf | St. Charles | 1977-1979 | | 15 | 56 | 0.268 |
| 29 | Kami Holt | Republic | 2013-2016 | | 27 | 108 | 0.250 |
| 29 | Ashley Fleming | Silex | 2004-2008 | | 25 | 100 | 0.250 |
| 29 | Ali Raley | Pierce City | 2014-2017 | | 25 | 100 | 0.250 |
| 32 | Marissa Peek | Holt | 2016-2019 | | 29 | 117 | 0.248 |
| 33 | Molly Carter | Hickman | 2011-2014 | | 26 | 105 | 0.248 |
| 34 | Paige McCord | Hallsville | 2018-2021 | | 22 | 89 | 0.247 |
| 35 | Dana M Graves | Weaubleau | 2009-2012 | | 26 | 109 | 0.239 |
| 36 | Savannah Fisher | Hallsville | 2011-2014 | | 21 | 90 | 0.233 |
| 37 | Emma Nichols | Hillsboro | 2015-2018 | | 27 | 117 | 0.231 |
| 38 | Caitlin Chapin | Ozark | 2005-2008 | | 27 | 120 | 0.225 |
| 39 | Meredith Hope Blakemore | Hallsville | 2020-2023 | | 21 | 95 | 0.221 |
| 40 | Kayla Patricia Ulrich | Sullivan | 2019-2022 | | 29 | 132 | 0.220 |
| 41 | Kylie DeClue | Park Hill South | 2012-2015 | | 24 | 111 | 0.216 |
| 42 | Marissa Dawn Austene | Hallsville | 2020-2023 | | 21 | 101 | 0.208 |
| 43 | Criswell, Hannah | Kennett | 2013-2016 | | 21 | 102 | 0.206 |
| 44 | Hanna Nicole Johanning | Sullivan | 2017-2020 | | 23 | 117 | 0.197 |
| 45 | Aubrey Christine Brown | Raymore-Peculiar | 2016-2019 | | 22 | 114 | 0.193 |
| 46 | Karsyn Brooke | Mansfield | 2015-2018 | | 24 | 132 | 0.182 |
| 47 | Lexi Whitaker | Trenton | 2017-2020 | | 18 | 103 | 0.175 |
| 48 | Salem Croy | Trenton | 2015-2018 | | 19 | 109 | 0.174 |
| 49 | | Montgomery County | 2018-2021 | | 15 | 87 | 0.172 |
| 50 | Hailey Presley | Marion C. Early | 2020-2023 | | 21 | 123 | 0.171 |
| 51 | Brittany Nimmo | Ozark | 2010-2013 | | 20 | 120 | 0.167 |
| 52 | Bailey Brumley | Blue Springs South | 2018-2021 | | 17 | 118 | 0.144 |
| 53 | Taylor Blehm | Marion C. Early | 2020-2023 | | 15 | 116 | 0.129 |