| Rank | Student | School | Years | | G | HR |
| 1 | Addie Lynn Morris | Rock Bridge | 2021-2024 | | 151 | 55 |
| 2 | Madison Marie Uptegrove | Father Tolton Regional Catholic | 2020-2023 | | 131 | 48 |
| 3 | Mac Lane Morgan | Sherwood | 2017-2020 | | 100 | 47 |
| 4 | Paige Eddington | Doniphan | 2014-2017 | | 134 | 43 |
| 4 | Abby Carol Hay | Rock Bridge | 2022-2023 | | 122 | 43 |
| 6 | Katie Ann Chester | Liberty North | 2018-2021 | | 114 | 42 |
| 7 | Taylor Hamilton | Cameron | 2011-2014 | | 104 | 41 |
| 7 | Anastasia Grace Mueller | Pacific | 2016-2019 | | 96 | 41 |
| 9 | Nicole Hudson | Webb City | 2005-2008 | | 117 | 40 |
| 10 | Addison Purvis | Sullivan | 2016-2019 | | 117 | 36 |
| 10 | Hannah Marie Cox | Sullivan | 2016-2019 | | 118 | 36 |
| 10 | Kara Kaye Daly | Jefferson City | 2017-2020 | | 104 | 36 |
| 13 | Maleigh Elizabeth Lemings | Holcomb | 2020-2023 | | 127 | 35 |
| 14 | Valerie Teter | Bevier | 2003-2006 | | 99 | 34 |
| 14 | Ashley Ellis | Fox | 2012-2015 | | 113 | 34 |
| 14 | Carlie Sanders | Hillsboro | 2014-2017 | | 107 | 34 |
| 14 | Nya Morgan | Ozark | 2015-2018 | | 130 | 34 |
| 14 | Audrey Carlton | Ozark | 2021-2024 | | 139 | 34 |
| 19 | Sierra Culver | Kearney | 2016-2019 | | 112 | 31 |
| 20 | Shelby Ann-Renee Webster | Camdenton | 2015-2018 | | 102 | 30 |
| 21 | Jessica Damico | Pacific | 2007-2010 | | 94 | 29 |
| 21 | Jordan Shewmaker | Buffalo | 2010-2013 | | 98 | 29 |
| 21 | Marissa Peek | Holt | 2016-2019 | | 117 | 29 |
| 21 | Maci Moore | Trenton | 2018-2021 | | 106 | 29 |
| 21 | Kayla Patricia Ulrich | Sullivan | 2019-2022 | | 132 | 29 |
| 26 | Maris Ollison | Versailles | 2018-2021 | | 103 | 28 |
| 27 | Caitlin Chapin | Ozark | 2005-2008 | | 120 | 27 |
| 27 | Kami Holt | Republic | 2013-2016 | | 108 | 27 |
| 27 | Emma Nichols | Hillsboro | 2015-2018 | | 117 | 27 |
| 27 | Erin McPike | East Buchanan | 2017-2020 | | 91 | 27 |
| 31 | Dana M Graves | Weaubleau | 2009-2012 | | 109 | 26 |
| 31 | Molly Carter | Hickman | 2011-2014 | | 105 | 26 |
| 31 | Kimmora Carothers | Jackson | 2021-2024 | | 98 | 26 |
| 34 | Ashley Fleming | Silex | 2004-2008 | | 100 | 25 |
| 34 | Ali Raley | Pierce City | 2014-2017 | | 100 | 25 |
| 36 | Kylie DeClue | Park Hill South | 2012-2015 | | 111 | 24 |
| 36 | Karsyn Brooke | Mansfield | 2015-2018 | | 132 | 24 |
| 38 | Kreslee Jo Ketcham | Neosho | 2005-2008 | | 111 | 23 |
| 38 | Adrienne Compton | Hancock | 2012-2015 | | 70 | 23 |
| 38 | Hanna Nicole Johanning | Sullivan | 2017-2020 | | 117 | 23 |
| 41 | Aubrey Christine Brown | Raymore-Peculiar | 2016-2019 | | 114 | 22 |
| 41 | Paige McCord | Hallsville | 2018-2021 | | 89 | 22 |
| 43 | Savannah Fisher | Hallsville | 2011-2014 | | 90 | 21 |
| 43 | Criswell, Hannah | Kennett | 2013-2016 | | 102 | 21 |
| 43 | Marissa Dawn Austene | Hallsville | 2020-2023 | | 101 | 21 |
| 43 | Meredith Hope Blakemore | Hallsville | 2020-2023 | | 95 | 21 |
| 43 | Hailey Presley | Marion C. Early | 2020-2023 | | 123 | 21 |
| 43 | Kylie Walker | Senath-Hornersville | 2021-2022 | | 32 | 21 |
| 43 | Haleigh A Winter | Highland | 2021-2024 | | 117 | 21 |
| 50 | Brittany Nimmo | Ozark | 2010-2013 | | 120 | 20 |
| 51 | Salem Croy | Trenton | 2015-2018 | | 109 | 19 |
| 51 | Blaire Riley | Kelly | 2021-2024 | | 122 | 19 |
| 53 | Lexi Whitaker | Trenton | 2017-2020 | | 103 | 18 |
| 54 | Bailey Brumley | Blue Springs South | 2018-2021 | | 118 | 17 |
| 55 | Cindy Wolf | St. Charles | 1977-1979 | | 56 | 15 |
| 55 | | Montgomery County | 2018-2021 | | 87 | 15 |
| 55 | | Montgomery County | 2018-2021 | | 87 | 15 |
| 55 | Taylor Blehm | Marion C. Early | 2020-2023 | | 116 | 15 |