| Rank | Student | School | Years | | 3B | G | AVG |
| 1 | Sydney McKinney | Norborne | 2014-2017 | | 34 | 98 | .347 |
| 2 | Josie Knesel | Ursuline Academy | 2010-2013 | | 26 | 85 | .306 |
| 3 | Keira Chrisco | Rolla | 2018-2021 | | 33 | 116 | .284 |
| 4 | Paige Eddington | Doniphan | 2014-2017 | | 37 | 134 | .276 |
| 5 | Zoe Brittan | Valley Park | 2004-2006 | | 20 | 74 | .270 |
| 6 | Katie Wood | Norborne | 2013-2016 | | 23 | 94 | .245 |
| 7 | Tabitha Francka | Marion C. Early | 2012-2015 | | 23 | 95 | .242 |
| 8 | Jenni Niemira | Cor Jesu Academy | 1989-1990 | | 13 | 54 | .241 |
| 9 | Michelle Madden | Jefferson (Conception) | 1986-1989 | | 13 | 56 | .232 |
| 10 | Adrienne Compton | Hancock | 2012-2015 | | 16 | 70 | .229 |
| 11 | Jayne Miller | Palmyra | 1995-1998 | | 19 | 85 | .224 |
| 12 | Mikala Torrence | Hillsboro | 2008-2011 | | 24 | 109 | .220 |
| 13 | Maggie Viefhaus | Eureka | 2002-2005 | | 22 | 100 | .220 |
| 14 | Halle Gooch | Clearwater | 2014-2017 | | 20 | 93 | .215 |
| 15 | Julie Taylor | Glendale | 2000-2003 | | 21 | 99 | .212 |
| 16 | Maleigh Elizabeth Lemings | Holcomb | 2020-2023 | | 25 | 127 | .197 |
| 17 | Ali Raley | Pierce City | 2014-2017 | | 16 | 100 | .160 |
| 18 | Cali Coombs | Russellville | 2019-2022 | | 18 | 115 | .157 |
| 19 | Grace S Parrott | Sherwood | 2016-2019 | | 16 | 103 | .155 |
| 20 | Lauren Taylor | Marion C. Early | 2019-2022 | | 14 | 96 | .146 |
| 21 | Kaetlyn Reece Danley | Holcomb | 2020-2023 | | 17 | 126 | .135 |
| 22 | Elle Smith | Blue Springs South | 2018-2021 | | 12 | 98 | .122 |
| 23 | Lexi Whitaker | Trenton | 2017-2020 | | 12 | 103 | .117 |
| 24 | Hailey Presley | Marion C. Early | 2020-2023 | | 13 | 123 | .106 |
| 25 | Karsyn Brooke | Mansfield | 2015-2018 | | 13 | 132 | .098 |
| 25 | Kayla Patricia Ulrich | Sullivan | 2019-2022 | | 13 | 132 | .098 |