| Rank | Student | School | Years | | G | 3B |
| 1 | Paige Eddington | Doniphan | 2014-2017 | | 134 | 37 |
| 2 | Sydney McKinney | Norborne | 2014-2017 | | 98 | 34 |
| 3 | Keira Chrisco | Rolla | 2018-2021 | | 116 | 33 |
| 4 | Josie Knesel | Ursuline Academy | 2010-2013 | | 85 | 26 |
| 5 | Maleigh Elizabeth Lemings | Holcomb | 2020-2023 | | 127 | 25 |
| 6 | Mikala Torrence | Hillsboro | 2008-2011 | | 109 | 24 |
| 7 | Tabitha Francka | Marion C. Early | 2012-2015 | | 95 | 23 |
| 7 | Katie Wood | Norborne | 2013-2016 | | 94 | 23 |
| 9 | Maggie Viefhaus | Eureka | 2002-2005 | | 100 | 22 |
| 10 | Joy Puricelli | Lutheran South | 1996-1999 | | 106 | 21 |
| 10 | Julie Taylor | Glendale | 2000-2003 | | 99 | 21 |
| 12 | Zoe Brittan | Valley Park | 2004-2006 | | 74 | 20 |
| 12 | Halle Gooch | Clearwater | 2014-2017 | | 93 | 20 |
| 14 | Jayne Miller | Palmyra | 1995-1998 | | 85 | 19 |
| 14 | Alexis Van Nostrand | Palmyra | 2009-2012 | | 124 | 19 |
| 16 | Cali Coombs | Russellville | 2019-2022 | | 115 | 18 |
| 17 | Kaetlyn Reece Danley | Holcomb | 2020-2023 | | 126 | 17 |
| 18 | Micah Elizabeth Scharff | Ladue Horton Watkins | 2007-2010 | | 80 | 16 |
| 18 | Adrienne Compton | Hancock | 2012-2015 | | 70 | 16 |
| 18 | Ali Raley | Pierce City | 2014-2017 | | 100 | 16 |
| 18 | Grace S Parrott | Sherwood | 2016-2019 | | 103 | 16 |
| 22 | Lauren Taylor | Marion C. Early | 2019-2022 | | 96 | 14 |
| 23 | Karsyn Brooke | Mansfield | 2015-2018 | | 132 | 13 |
| 23 | Kayla Patricia Ulrich | Sullivan | 2019-2022 | | 132 | 13 |
| 23 | Hailey Presley | Marion C. Early | 2020-2023 | | 123 | 13 |
| 26 | Lexi Whitaker | Trenton | 2017-2020 | | 103 | 12 |
| 26 | Elle Smith | Blue Springs South | 2018-2021 | | 98 | 12 |