| Rank | Student | School | Years | | 2B | G | Total |
| 1 | Ali Raley | Pierce City | 2014-2017 | | 66 | 100 | 0.660 |
| 2 | Madison McKinney | Norborne | 2012-2015 | | 61 | 96 | 0.635 |
| 3 | Tabitha Francka | Marion C. Early | 2012-2015 | | 54 | 95 | 0.568 |
| 4 | Marin Whorton | Ozark | 1993-1996 | | 45 | 87 | 0.517 |
| 5 | Sarah Roth | Northwest (Cedar Hill) | 2017-2020 | | 58 | 113 | 0.513 |
| 6 | Sara Harvey | Staley | 2010-2013 | | 49 | 98 | 0.500 |
| 7 | Emma Nichols | Hillsboro | 2015-2018 | | 57 | 117 | 0.487 |
| 8 | Kylie Marie Helm | McDonald County | 2015-2018 | | 54 | 112 | 0.482 |
| 9 | Kali Nelson | Dixon | 2012-2015 | | 47 | 98 | 0.480 |
| 10 | Brittany Smith | Seckman | 2006-2010 | | 45 | 99 | 0.455 |
| 11 | Sammey Clara Bunch | Fatima | 2012-2015 | | 49 | 108 | 0.454 |
| 12 | Addison Purvis | Sullivan | 2016-2019 | | 53 | 117 | 0.453 |
| 13 | Mac Lane Morgan | Sherwood | 2017-2020 | | 45 | 100 | 0.450 |
| 14 | Sophia Gentry | Bishop LeBlond | 2010-2013 | | 49 | 111 | 0.441 |
| 15 | Micah Elizabeth Scharff | Ladue Horton Watkins | 2007-2010 | | 35 | 80 | 0.438 |
| 16 | Tara Verkuilen | Schuyler County | 2004-2007 | | 33 | 76 | 0.434 |
| 17 | Alexis Ralls | Notre Dame (Cape Girardeau) | 2005-2008 | | 28 | 65 | 0.431 |
| 18 | Brooke Huitt | Lathrop | 2015-2018 | | 47 | 113 | 0.416 |
| 19 | Hannah Marie Cox | Sullivan | 2016-2019 | | 47 | 118 | 0.398 |
| 20 | Paige Eddington | Doniphan | 2014-2017 | | 53 | 134 | 0.396 |
| 21 | Hanna Nicole Johanning | Sullivan | 2017-2020 | | 46 | 117 | 0.393 |
| 22 | Karsyn Brooke | Mansfield | 2015-2018 | | 50 | 132 | 0.379 |
| 23 | Morgan Hull | Mt. Vernon | 2013-2016 | | 42 | 111 | 0.378 |