| Rank | Student | School | Years | | G | 2B |
| 1 | Kayla Patricia Ulrich | Sullivan | 2019-2022 | | 132 | 68 |
| 2 | Ali Raley | Pierce City | 2014-2017 | | 100 | 66 |
| 3 | Madison Marie Uptegrove | Father Tolton Regional Catholic | 2020-2023 | | 131 | 63 |
| 3 | Kaetlyn Reece Danley | Holcomb | 2020-2023 | | 126 | 63 |
| 5 | Madison McKinney | Norborne | 2012-2015 | | 96 | 61 |
| 6 | Cali Coombs | Russellville | 2019-2022 | | 115 | 59 |
| 7 | Sarah Roth | Northwest (Cedar Hill) | 2017-2020 | | 113 | 58 |
| 8 | Emma Nichols | Hillsboro | 2015-2018 | | 117 | 57 |
| 8 | Carli Layne Cook | Plato | 2021-2024 | | 104 | 57 |
| 10 | Hailey Presley | Marion C. Early | 2020-2023 | | 123 | 56 |
| 11 | Tabitha Francka | Marion C. Early | 2012-2015 | | 95 | 54 |
| 11 | Kylie Marie Helm | McDonald County | 2015-2018 | | 112 | 54 |
| 11 | Blaire Riley | Kelly | 2021-2024 | | 122 | 54 |
| 14 | Paige Eddington | Doniphan | 2014-2017 | | 134 | 53 |
| 14 | Addison Purvis | Sullivan | 2016-2019 | | 117 | 53 |
| 16 | Riley Wilkinson | Marshall | 2021-2024 | | 93 | 52 |
| 17 | Maleigh Elizabeth Lemings | Holcomb | 2020-2023 | | 127 | 51 |
| 18 | Karsyn Brooke | Mansfield | 2015-2018 | | 132 | 50 |
| 19 | Sara Harvey | Staley | 2010-2013 | | 98 | 49 |
| 19 | Sophia Gentry | Bishop LeBlond | 2010-2013 | | 111 | 49 |
| 19 | Sammey Clara Bunch | Fatima | 2012-2015 | | 108 | 49 |
| 22 | Kali Nelson | Dixon | 2012-2015 | | 98 | 47 |
| 22 | Makenzie Goswick | Joplin | 2012-2015 | | 120 | 47 |
| 22 | Brooke Huitt | Lathrop | 2015-2018 | | 113 | 47 |
| 22 | Hannah Marie Cox | Sullivan | 2016-2019 | | 118 | 47 |
| 26 | Hanna Nicole Johanning | Sullivan | 2017-2020 | | 117 | 46 |
| 27 | Marin Whorton | Ozark | 1993-1996 | | 87 | 45 |
| 27 | Brittany Rozier | Timberland | 2006-2009 | | 111 | 45 |
| 27 | Brittany Smith | Seckman | 2006-2010 | | 99 | 45 |
| 27 | Mac Lane Morgan | Sherwood | 2017-2020 | | 100 | 45 |
| 31 | Madelyn Stichling | Northwest (Cedar Hill) | 2018-2021 | | 114 | 43 |
| 32 | Maggie Viefhaus | Eureka | 2002-2005 | | 100 | 42 |
| 32 | Caitlin Chapin | Ozark | 2005-2008 | | 120 | 42 |
| 32 | Lauren Fuller | Rock Bridge | 2008-2011 | | 114 | 42 |
| 32 | Dana M Graves | Weaubleau | 2009-2012 | | 109 | 42 |
| 32 | Morgan Hull | Mt. Vernon | 2013-2016 | | 111 | 42 |
| 32 | Payton Miller | Highland | 2019-2022 | | 98 | 42 |
| 38 | Maci Moore | Trenton | 2018-2021 | | 106 | 41 |
| 39 | Kirsten Dunn | Chillicothe | 2019-2022 | | 106 | 40 |