| Rank | Student | School | Years | | G | Total |
| 1 | Abigail Chipps | Jefferson (Festus) | 2016-2019 | | 98 | 188 |
| 2 | Cheyenne Pratt | Festus | 2010-2013 | | 106 | 184 |
| 2 | Audrey Glenski | Bishop LeBlond | 2011-2014 | | 103 | 184 |
| 4 | Ali Raley | Pierce City | 2014-2017 | | 100 | 182 |
| 5 | Katie B Kroeger | Northwest (Cedar Hill) | 2006-2009 | | 110 | 171 |
| 6 | Sydney Miller | Willow Springs | 2015-2018 | | 105 | 161 |
| 7 | Emily Crane | Troy Buchanan | 2008-2011 | | 118 | 151 |
| 8 | Erika Reinagel | Notre Dame (Cape Girardeau) | 2005-2008 | | 120 | 150 |
| 9 | Lillian Grace Knesel | Marquette | 2014-2017 | | 95 | 149 |
| 9 | Abigail Rickermann | Festus | 2016-2019 | | 102 | 149 |
| 11 | Julie Silver | Parkway Central | 2002-2005 | | 103 | 145 |
| 12 | Skyler Hime | Raymore-Peculiar | 2011-2014 | | 111 | 142 |
| 13 | Olivia Jo Pfeifer | Hannibal | 2014-2017 | | 95 | 141 |
| 14 | Sydney McKinney | Norborne | 2014-2017 | | 98 | 140 |
| 15 | Mykaela Alexi Arellanes | Holt | 2011-2014 | | 105 | 139 |
| 15 | Makenzie Goswick | Joplin | 2012-2015 | | 120 | 139 |
| 17 | Sophia Luetticke | Chillicothe | 2018-2021 | | 94 | 136 |
| 18 | Katelin Ann Kurima | Monett | 2014-2017 | | 102 | 132 |
| 19 | Grace S Parrott | Sherwood | 2016-2019 | | 103 | 131 |
| 20 | Regan Nash | North Platte | 2011-2014 | | 94 | 128 |