| Rank | Student | School | Years | | G | AB |
| 1 | Cydney Annmarie Fullerton | Rock Bridge | 2020-2023 | | 141 | 444 |
| 2 | Addie Lynn Morris | Rock Bridge | 2021-2024 | | 151 | 428 |
| 3 | Makenzie Goswick | Joplin | 2012-2015 | | 120 | 427 |
| 4 | Tamarah Myers | Joplin | 2012-2015 | | 119 | 400 |
| 5 | Emily Crane | Troy Buchanan | 2008-2011 | | 118 | 396 |
| 6 | Karen Weatherly | Lutheran South | 1999-2002 | | 120 | 394 |
| 7 | Kayla Patricia Ulrich | Sullivan | 2019-2022 | | 132 | 393 |
| 8 | Christa Reisinger | Troy Buchanan | 2011-2014 | | 113 | 392 |
| 9 | Jamie Lynn Holmes | Republic | 2005-2008 | | 114 | 389 |
| 9 | Hailey Presley | Marion C. Early | 2020-2023 | | 123 | 389 |
| 11 | Leanne Bowers | Seckman | 1999-2002 | | 112 | 388 |
| 12 | Karsyn Brooke | Mansfield | 2015-2018 | | 132 | 387 |
| 13 | Bella Grace Stephens | Rock Bridge | 2021-2024 | | 126 | 385 |
| 14 | Taylor Cowan | Hickman | 2005-2008 | | 104 | 384 |
| 15 | Ashley Nelson | Mansfield | 2015-2018 | | 135 | 383 |
| 15 | Sarah Roth | Northwest (Cedar Hill) | 2017-2020 | | 113 | 383 |
| 17 | Kimberly Ann Ruth | Rolla | 2005-2008 | | 106 | 381 |
| 18 | Erin Stremstyfer | Parkway South | 1993-1996 | | 75 | 380 |
| 19 | Blaire Riley | Kelly | 2021-2024 | | 29 | 376 |