| Rank | Student | School | Years | | G | PA |
| 1 | Kayla Patricia Ulrich | Sullivan | 2019-2022 | | 132 | 480 |
| 2 | Karsyn Brooke | Mansfield | 2015-2018 | | 132 | 466 |
| 3 | Makenzie Goswick | Joplin | 2012-2015 | | 120 | 461 |
| 4 | Hailey Presley | Marion C. Early | 2020-2023 | | 123 | 440 |
| 5 | Sarah Roth | Northwest (Cedar Hill) | 2017-2020 | | 113 | 439 |
| 6 | Addison Purvis | Sullivan | 2016-2019 | | 117 | 438 |
| 7 | Emily Crane | Troy Buchanan | 2011-2014 | | 113 | 436 |
| 7 | Christa Reisinger | Troy Buchanan | 2011-2014 | | 113 | 436 |
| 9 | Hannah Marie Cox | Sullivan | 2016-2019 | | 118 | 434 |
| 10 | Alexis Van Nostrand | Palmyra | 2009-2012 | | 124 | 433 |
| 11 | Tamarah Myers | Joplin | 2008-2011 | | 119 | 429 |
| 12 | Cheyenne Pratt | Festus | 2010-2013 | | 106 | 428 |
| 13 | Erika Reinagel | Notre Dame (Cape Girardeau) | 2005-2008 | | 120 | 422 |
| 14 | Caitlin Chapin | Ozark | 2005-2008 | | 120 | 420 |
| 14 | Sophia Gentry | Bishop LeBlond | 2010-2013 | | 111 | 420 |
| 14 | Keira Chrisco | Rolla | 2018-2021 | | 116 | 420 |
| 17 | | Jasper | 2021-2023 | | 114 | 418 |
| 18 | Jamie Lynn Holmes | Republic | 2005-2008 | | 114 | 416 |