| Rank | Student | Grade | School | Year | | W | G | Total |
| 1 | Madison Thomas | Sr | Madison | 2018 | | 32 | 21 | 1.524 |
| 1 | Madison Thomas | Sr | Madison | 2018 | | 32 | 21 | 1.524 |
| 3 | Bev Darnell | Sr | St. Charles | 1978 | | 23 | 16 | 1.438 |
| 4 | Sarah Woods | Sr | Hancock | 2006 | | 27 | 19 | 1.421 |
| 5 | Marissa Lewis | Sr | Metro | 2006 | | 35 | 26 | 1.346 |
| 6 | Ali Raley | Sr | Pierce City | 2017 | | 33 | 25 | 1.320 |
| 7 | Katy Roberts | Sr | Schuyler County | 2002 | | 29 | 22 | 1.318 |
| 8 | Amanda Newman | Fr | Hancock | 2006 | | 23 | 19 | 1.211 |
| 9 | Traneice Greer | Sr | Jennings | 2006 | | 24 | 20 | 1.200 |
| 10 | Ashton N Miller | Jr | Northwest (Hughesville) | 2007 | | 19 | 16 | 1.188 |
| 11 | Destinee Greathouse | Jr | Sarcoxie | 2011 | | 27 | 23 | 1.174 |
| 12 | Holly Plummer | Sr | Valley Park | 2006 | | 28 | 24 | 1.167 |
| 12 | Lauren Duffy | Sr | St. Charles | 1982 | | 21 | 18 | 1.167 |
| 14 | Taylor J. Kennedy | So | Hancock | 2007 | | 24 | 21 | 1.143 |
| 15 | Meredith Kathryn Norfleet | Fr | Northwest (Hughesville) | 2007 | | 18 | 16 | 1.125 |
| 16 | Olivia H. Pilsing | Jr | St. Charles | 2017 | | 27 | 25 | 1.080 |
| 17 | Alyson Marcum | So | Bernie | 2017 | | 25 | 26 | 0.962 |
| 18 | Addison Purvis | Jr | Sullivan | 2018 | | 26 | 33 | 0.788 |