| Rank | Student | Grade | School | Year | | TB | AB | Total |
| 1 | Ali Raley | Sr | Pierce City | 2017 | | 104 | 59 | 1.763 |
| 2 | | Sr | Brashear | 2019 | | 89 | 56 | 1.589 |
| 3 | Amelia Ayotte | So | Brentwood | 2018 | | 81 | 52 | 1.558 |
| 4 | Ashley Fleming | Jr | Silex | 2006 | | 100 | 68 | 1.471 |
| 5 | Amelia Ayotte | Jr | Brentwood | 2019 | | 70 | 48 | 1.458 |
| 6 | Kaileigh Marie Dirden | Fr | Scott City | 2016 | | 112 | 77 | 1.455 |
| 7 | Alyson Marcum | So | Bernie | 2017 | | 110 | 76 | 1.447 |
| 8 | Carlie Anne Rose | Jr | Nixa | 2010 | | 117 | 81 | 1.444 |
| 9 | Natalee Moore | Fr | Grandview (Hillsboro) | 2018 | | 74 | 52 | 1.423 |
| 10 | Sammey Clara Bunch | Sr | Fatima | 2015 | | 141 | 102 | 1.382 |
| 11 | Nicole Hudson | So | Webb City | 2006 | | 93 | 68 | 1.368 |
| 12 | Tabitha Francka | Sr | Marion C. Early | 2015 | | 94 | 69 | 1.362 |
| 13 | Addison Purvis | Sr | Sullivan | 2019 | | 92 | 68 | 1.353 |
| 14 | Valerie Teter | Sr | Bevier | 2006 | | 96 | 71 | 1.352 |
| 15 | Micah Elizabeth Scharff | Sr | Ladue Horton Watkins | 2010 | | 77 | 57 | 1.351 |
| 16 | Addison Purvis | So | Sullivan | 2017 | | 117 | 87 | 1.345 |
| 17 | Maris Ollison | Jr | Versailles | 2020 | | 102 | 77 | 1.325 |
| 18 | Valerie Teter | Jr | Bevier | 2005 | | 94 | 71 | 1.324 |
| 19 | Katie Ann Chester | Sr | Liberty North | 2021 | | 133 | 101 | 1.317 |
| 20 | Morgan Loggins | Sr | Waynesville | 2017 | | 109 | 84 | 1.298 |
| 21 | Tara Verkuilen | Sr | Schuyler County | 2007 | | 70 | 54 | 1.296 |
| 22 | Shekinah Reed | Jr | Brentwood | 2018 | | 68 | 55 | 1.236 |
| 23 | Kayla Patricia Ulrich | Jr | Sullivan | 2021 | | 132 | 114 | 1.158 |
| 24 | Maleigh Lemings | So | Holcomb | 2021 | | 104 | 95 | 1.095 |
| 25 | Maleigh Elizabeth Lemings | Fr | Holcomb | 2020 | | 97 | 93 | 1.043 |