| Rank | Student | Grade | School | Year | | HR | G | Total |
| 1 | Megan Spring | So | Warsaw | 1997 | | 10 | 14 | 0.714 |
| 2 | Carlie Sanders | Sr | Hillsboro | 2017 | | 21 | 30 | 0.700 |
| 3 | Kaileigh Marie Dirden | Fr | Scott City | 2016 | | 16 | 23 | 0.696 |
| 4 | Cindy Wolf | Jr | St. Charles | 1978 | | 11 | 16 | 0.688 |
| 5 | Anastasia Grace Mueller | Jr | Pacific | 2018 | | 15 | 23 | 0.652 |
| 6 | Jessica Damico | Jr | Pacific | 2009 | | 15 | 24 | 0.625 |
| 7 | Maris Ollison | Jr | Versailles | 2020 | | 16 | 27 | 0.593 |
| 8 | | Sr | Kennett | 2016 | | 15 | 26 | 0.577 |
| 9 | Emily Frankenreiter | Sr | Lutheran South | 2015 | | 16 | 28 | 0.571 |
| 10 | Ali Raley | Sr | Pierce City | 2017 | | 14 | 25 | 0.560 |
| 11 | Haidyn Berry | Sr | Webb City | 2020 | | 18 | 33 | 0.545 |
| 12 | Amanda Fitzwilliam | Sr | Oakville | 2019 | | 13 | 24 | 0.542 |
| 13 | Julia Higgins | Sr | Republic | 2018 | | 15 | 28 | 0.536 |
| 14 | Kinsey J Fiedler | Sr | Lee's Summit North | 2020 | | 17 | 32 | 0.531 |
| 15 | Katie Ann Chester | Sr | Liberty North | 2021 | | 18 | 34 | 0.529 |
| 16 | Nicole Hudson | So | Webb City | 2006 | | 13 | 25 | 0.520 |
| 17 | Kelsey Claire Lenox | Jr | Marquette | 2016 | | 15 | 29 | 0.517 |
| 17 | Shelby Ann-Renee Webster | Sr | Camdenton | 2018 | | 15 | 29 | 0.517 |
| 19 | Nya Morgan | Sr | Ozark | 2018 | | 17 | 33 | 0.515 |
| 20 | Ashley Ellis | Sr | Fox | 2015 | | 16 | 32 | 0.500 |
| 20 | Kelsey Boyd | Jr | Hillsboro | 2017 | | 15 | 30 | 0.500 |
| 20 | Sydney Washington | Sr | Hickman | 2012 | | 14 | 28 | 0.500 |
| 20 | Valerie Teter | Jr | Bevier | 2005 | | 13 | 26 | 0.500 |
| 20 | Ashley Fleming | Jr | Silex | 2006 | | 13 | 26 | 0.500 |
| 20 | Taylor Hamilton | Fr | Cameron | 2011 | | 13 | 26 | 0.500 |
| 20 | Jordan Shewmaker | Sr | Buffalo | 2013 | | 13 | 26 | 0.500 |
| 20 | Alyson Marcum | So | Bernie | 2017 | | 13 | 26 | 0.500 |
| 20 | Christina Allen | Sr | Notre Dame (St. Louis) | 2013 | | 10 | 20 | 0.500 |
| 29 | Mac Morgan | Jr | Sherwood | 2019 | | 14 | 29 | 0.483 |
| 29 | Abby Hay | So | Rock Bridge | 2020 | | 14 | 29 | 0.483 |
| 31 | Emma Ray | Jr | Iberia | 2019 | | 10 | 21 | 0.476 |
| 32 | Callie Martin | Sr | Raymore-Peculiar | 2017 | | 13 | 28 | 0.464 |
| 33 | Delanie Freeze | Sr | Liberal | 2017 | | 12 | 26 | 0.462 |
| 34 | Kara Kaye Daly | So | Jefferson City | 2018 | | 12 | 27 | 0.444 |
| 34 | Addison Purvis | Sr | Sullivan | 2019 | | 12 | 27 | 0.444 |
| 36 | Hannah Marie Cox | Sr | Sullivan | 2019 | | 14 | 32 | 0.438 |
| 37 | Addison Purvis | So | Sullivan | 20 | | 13 | 30 | 0.433 |
| 38 | Aubrey Christine Brown | Jr | Raymore-Peculiar | 2018 | | 13 | 33 | 0.394 |
| 39 | Lexi Whitaker | Sr | Trenton | 2019 | | 9 | 24 | 0.375 |
| 40 | Kami Holt | So | Republic | 2014 | | 11 | 30 | 0.367 |
| 41 | Caitlin Chapin | Jr | Ozark | 2007 | | 11 | 33 | 0.333 |
| 41 | Maci Moore | So | Trenton | 2019 | | 10 | 30 | 0.333 |
| 43 | Kayla Patricia Ulrich | Jr | Sullivan | 2021 | | 12 | 37 | 0.324 |
| 44 | Brittany Nimmo | Sr | Ozark | 2013 | | 9 | 29 | 0.310 |
| 45 | Maleigh Elizabeth Lemings | Fr | Holcomb | 2020 | | 8 | 30 | 0.267 |