| Rank | Student | Grade | School | Year | | G | PA |
| 1 | Macie Botsch | Sr | Bernie | 2024 | Spring 2025 | 36 | 153 |
| 2 | Cydney Annmarie Fullerton | Jr | Rock Bridge | 2022 | | 39 | 152 |
| 3 | | So | Farmington | 2021 | | 37 | 148 |
| 3 | Blair Pleimling | Jr | Bernie | 2024 | Spring 2025 | 36 | 148 |
| 5 | Bella Grace Stephens | Sr | Rock Bridge | 2024 | | 38 | 147 |
| 6 | Abby Robbins | Sr | Farmington | 2021 | | 37 | 144 |
| 6 | Cydney Annmarie Fullerton | So | Rock Bridge | 2021 | | 36 | 144 |
| 8 | Hannah Heisler | Jr | Fatima | 2022 | | 36 | 143 |
| 8 | Abby Carol Hay | Sr | Rock Bridge | 2022 | | 39 | 143 |
| 8 | Addie Lynn Morris | Sr | Rock Bridge | 2024 | | 39 | 143 |
| 11 | Makenzie Goswick | Sr | Joplin | 2015 | | 35 | 141 |
| 11 | Keira Chrisco | Sr | Rolla | 2021 | | 40 | 141 |
| 11 | Kayla Patricia Ulrich | Jr | Sullivan | 2021 | | 37 | 141 |
| 11 | Kirsten Dunn | Sr | Chillicothe | 2022 | | 35 | 141 |
| 11 | Livia Dumm | Jr | Jasper | 2022 | | 36 | 141 |
| 11 | Molly Daniels | So | Mt. Vernon | 2022 | | 38 | 141 |
| 11 | Anna Grace Christ | Sr | Rock Bridge | 2022 | | 39 | 141 |
| 11 | Bella Grace Stephens | So | Rock Bridge | 2022 | | 39 | 141 |
| 19 | Courtney Swink | Sr | Farmington | 2021 | | 37 | 138 |
| 19 | Ava Marie Bush | Jr | Rock Bridge | 2024 | | 39 | 138 |
| 21 | Riley Branson | Sr | Sullivan | 2021 | | 37 | 137 |
| 22 | Payge Evans | Jr | Mt. Vernon | 2022 | | 35 | 136 |
| 22 | Faith Lauren Jaegers | Sr | Fatima | 2023 | | 39 | 136 |
| 24 | Angelia Davis | Jr | Farmington | 2021 | | 37 | 135 |
| 25 | Gabriella Haddock | Jr | Jasper | 2022 | | 36 | 134 |
| 25 | Kennedy Lee Diggs | Jr | Sherwood | 2022 | | 36 | 134 |
| 25 | Kennedy Nicole Watson | Jr | Rock Bridge | 2024 | | 39 | 134 |
| 28 | Lillian Grace Knesel | Sr | Marquette | 2017 | | 32 | 132 |
| 28 | Peyton Hawkins | Jr | Webb City | 2020 | | 33 | 132 |
| 28 | Sophia Ann-Marie Weirich | Sr | Sullivan | 2021 | | 37 | 132 |
| 28 | Rebekah R Riffle | Sr | Sherwood | 2022 | | 36 | 132 |
| 32 | Emily Crane | Sr | Troy Buchanan | 2011 | | 33 | 131 |
| 32 | Hope Helton | Sr | Chillicothe | 2022 | | 35 | 131 |
| 34 | Peyton Corrigan | Sr | Holden | 2018 | | 32 | 130 |
| 34 | Kinlei Boley | Sr | Chillicothe | 2022 | | 35 | 130 |
| 36 | Sophia Luetticke | Sr | Chillicothe | 2021 | | 35 | 129 |
| 36 | Taylor Hinds | Jr | Jasper | 2022 | | 36 | 129 |
| 36 | Allison Schubert | Sr | Mt. Vernon | 2022 | | 38 | 129 |
| 39 | Kaesha George | Jr | Monett | 2018 | | 32 | 128 |
| 39 | Addison Purvis | Jr | Sullivan | 2018 | | 33 | 128 |
| 39 | Madison White | Sr | Rock Bridge | 2019 | | 35 | 128 |
| 39 | Breanna Pithan | Sr | Chillicothe | 2022 | | 35 | 128 |
| 43 | Emma Welch | Jr | Webb City | 2020 | | 33 | 127 |
| 44 | Alexis Van Nostrand | Sr | Palmyra | 2012 | | 31 | 126 |
| 44 | Hope Helton | Jr | Chillicothe | 2021 | | 35 | 126 |
| 44 | Evvie Rae Blankenship | Fr | Sullivan | 2021 | | 37 | 126 |
| 47 | Maddison Brown | Sr | Mt. Vernon | 2016 | | 32 | 125 |
| 47 | Maddi Coones | Sr | Monett | 2018 | | 32 | 125 |
| 47 | Kamryn Lohden | Sr | Sullivan | 2018 | | 33 | 125 |
| 47 | Haidyn Berry | Sr | Webb City | 2020 | | 33 | 125 |
| 47 | Kinlei Boley | Jr | Chillicothe | 2021 | | 35 | 125 |
| 47 | Ava Gurley | Fr | Holcomb | 2022 | | 31 | 125 |
| 47 | Hayden Lee Bush | So | Rock Bridge | 2024 | | 39 | 125 |
| 54 | Jennifer Mills | Sr | Centralia | 2011 | | 31 | 124 |
| 54 | Karli Allen | Sr | Fox | 2015 | | 32 | 124 |
| 54 | Kinsley Stewart | Jr | Joplin | 2015 | | 35 | 124 |
| 54 | Sammey Clara Bunch | Sr | Fatima | 2015 | | 32 | 124 |
| 54 | Katelin Ann Kurima | Sr | Monett | 2017 | | 32 | 124 |
| 54 | Bridgette Swinford | Jr | Chaffee | 2017 | | 31 | 124 |
| 54 | Maggie Klover | Sr | Holden | 2018 | | 31 | 124 |
| 54 | Madigan Kate Gladbach | Jr | Rock Bridge | 2024 | | 39 | 124 |
| 62 | Bailee Bryant | Sr | Holden | 2018 | | 32 | 123 |
| 62 | Shiloh Layne Storm | So | Jasper | 2022 | | 36 | 123 |
| 62 | Lauren Taylor | Sr | Marion C. Early | 2022 | | 34 | 123 |
| 65 | Hanna Nicole Johanning | Jr | Sullivan | 2019 | | 32 | 122 |
| 65 | Kaetlyn Danley | Jr | Holcomb | 2022 | | 31 | 122 |
| 65 | Lexi Hunter | So | South Harrison | 2023 | | 32 | 122 |
| 65 | Lexi Hunter | Jr | South Harrison | 2024 | | 34 | 122 |
| 69 | Saige Bennett | Jr | South Harrison | 2022 | | 33 | 121 |
| 70 | Maleigh Lemings | Jr | Holcomb | 2022 | | 31 | 120 |
| 70 | Emersyn Alivia Bass | So | Jasper | 2022 | | 32 | 120 |
| 72 | Mikaela Cox | Sr | Joplin | 2015 | | 133 | 35 |
| 72 | Tamarah Mascher | Sr | Joplin | 2015 | | 129 | 35 |