| Rank | Student | Grade | School | Year | | G | PA |
| 1 | Cydney Annmarie Fullerton | Jr | Rock Bridge | 2022 | | 39 | 152 |
| 2 | | So | Farmington | 2021 | | 37 | 148 |
| 3 | Bella Grace Stephens | Sr | Rock Bridge | 2024 | | 38 | 147 |
| 4 | Cydney Annmarie Fullerton | So | Rock Bridge | 2021 | | 36 | 144 |
| 4 | Abby Robbins | Sr | Farmington | 2021 | | 37 | 144 |
| 6 | Hannah Heisler | Jr | Fatima | 2022 | | 36 | 143 |
| 6 | Abby Carol Hay | Sr | Rock Bridge | 2022 | | 39 | 143 |
| 6 | Addie Lynn Morris | Sr | Rock Bridge | 2024 | | 39 | 143 |
| 9 | Makenzie Goswick | Sr | Joplin | 2015 | | 35 | 141 |
| 9 | Kayla Patricia Ulrich | Jr | Sullivan | 2021 | | 37 | 141 |
| 9 | Keira Chrisco | Sr | Rolla | 2021 | | 40 | 141 |
| 9 | Kirsten Dunn | Sr | Chillicothe | 2022 | | 35 | 141 |
| 9 | Anna Grace Christ | Sr | Rock Bridge | 2022 | | 39 | 141 |
| 9 | Bella Grace Stephens | So | Rock Bridge | 2022 | | 39 | 141 |
| 9 | Molly Daniels | So | Mt. Vernon | 2022 | | 38 | 141 |
| 9 | Livia Dumm | Jr | Jasper | 2022 | | 36 | 141 |
| 17 | Courtney Swink | Sr | Farmington | 2021 | | 37 | 138 |
| 17 | Ava Marie Bush | Jr | Rock Bridge | 2024 | | 39 | 138 |
| 19 | Riley Branson | Sr | Sullivan | 2021 | | 37 | 137 |
| 20 | Payge Evans | Jr | Mt. Vernon | 2022 | | 35 | 136 |
| 20 | Faith Lauren Jaegers | Sr | Fatima | 2023 | | 39 | 136 |
| 22 | Angelia Davis | Jr | Farmington | 2021 | | 37 | 135 |
| 23 | Kennedy Lee Diggs | Jr | Sherwood | 2022 | | 36 | 134 |
| 23 | Gabriella Haddock | Jr | Jasper | 2022 | | 36 | 134 |
| 23 | Kennedy Nicole Watson | Jr | Rock Bridge | 2024 | | 39 | 134 |
| 26 | Lillian Grace Knesel | Sr | Marquette | 2017 | | 32 | 132 |
| 26 | Peyton Hawkins | Jr | Webb City | 2020 | | 33 | 132 |
| 26 | Sophia Ann-Marie Weirich | Sr | Sullivan | 2021 | | 37 | 132 |
| 26 | Rebekah R Riffle | Sr | Sherwood | 2022 | | 36 | 132 |
| 30 | Emily Crane | Sr | Troy Buchanan | 2011 | | 33 | 131 |
| 30 | Hope Helton | Sr | Chillicothe | 2022 | | 35 | 131 |
| 32 | Peyton Corrigan | Sr | Holden | 2018 | | 32 | 130 |
| 32 | Kinlei Boley | Sr | Chillicothe | 2022 | | 35 | 130 |
| 34 | Sophia Luetticke | Sr | Chillicothe | 2021 | | 35 | 129 |
| 34 | Allison Schubert | Sr | Mt. Vernon | 2022 | | 38 | 129 |
| 34 | Taylor Hinds | Jr | Jasper | 2022 | | 36 | 129 |
| 37 | Kaesha George | Jr | Monett | 2018 | | 32 | 128 |
| 37 | Addison Purvis | Jr | Sullivan | 2018 | | 33 | 128 |
| 37 | Madison White | Sr | Rock Bridge | 2019 | | 35 | 128 |
| 37 | Breanna Pithan | Sr | Chillicothe | 2022 | | 35 | 128 |
| 41 | Emma Welch | Jr | Webb City | 2020 | | 33 | 127 |
| 42 | Alexis Van Nostrand | Sr | Palmyra | 2012 | | 31 | 126 |
| 42 | Evvie Rae Blankenship | Fr | Sullivan | 2021 | | 37 | 126 |
| 42 | Hope Helton | Jr | Chillicothe | 2021 | | 35 | 126 |
| 45 | Maddison Brown | Sr | Mt. Vernon | 2016 | | 32 | 125 |
| 45 | Maddi Coones | Sr | Monett | 2018 | | 32 | 125 |
| 45 | Kamryn Lohden | Sr | Sullivan | 2018 | | 33 | 125 |
| 45 | Haidyn Berry | Sr | Webb City | 2020 | | 33 | 125 |
| 45 | Kinlei Boley | Jr | Chillicothe | 2021 | | 35 | 125 |
| 45 | Ava Gurley | Fr | Holcomb | 2022 | | 31 | 125 |
| 45 | Hayden Lee Bush | So | Rock Bridge | 2024 | | 39 | 125 |
| 52 | Jennifer Mills | Sr | Centralia | 2011 | | 31 | 124 |
| 52 | Sammey Clara Bunch | Sr | Fatima | 2015 | | 32 | 124 |
| 52 | Kinsley Stewart | Jr | Joplin | 2015 | | 35 | 124 |
| 52 | Karli Allen | Sr | Fox | 2015 | | 32 | 124 |
| 52 | Katelin Ann Kurima | Sr | Monett | 2017 | | 32 | 124 |
| 52 | Bridgette Swinford | Jr | Chaffee | 2017 | | 31 | 124 |
| 52 | Maggie Klover | Sr | Holden | 2018 | | 31 | 124 |
| 52 | Madigan Kate Gladbach | Jr | Rock Bridge | 2024 | | 39 | 124 |
| 60 | Bailee Bryant | Sr | Holden | 2018 | | 32 | 123 |
| 60 | Lauren Taylor | Sr | Marion C. Early | 2022 | | 34 | 123 |
| 60 | Shiloh Layne Storm | So | Jasper | 2022 | | 36 | 123 |
| 63 | Hanna Nicole Johanning | Jr | Sullivan | 2019 | | 32 | 122 |
| 63 | Kaetlyn Danley | Jr | Holcomb | 2022 | | 31 | 122 |
| 63 | Lexi Hunter | So | South Harrison | 2023 | | 32 | 122 |
| 63 | Lexi Hunter | Jr | South Harrison | 2024 | | 34 | 122 |
| 67 | Saige Bennett | Jr | South Harrison | 2022 | | 33 | 121 |
| 68 | Maleigh Lemings | Jr | Holcomb | 2022 | | 31 | 120 |
| 68 | Emersyn Alivia Bass | So | Jasper | 2022 | | 32 | 120 |
| 70 | Mikaela Cox | Sr | Joplin | 2015 | | 133 | 35 |
| 70 | Tamarah Mascher | Sr | Joplin | 2015 | | 129 | 35 |