| Rank | Student | Grade | School | Year | | G | Total |
| 1 | | So | Farmington | 2021 | | 37 | 148 |
| 2 | Cydney Annmarie Fullerton | So | Rock Bridge | 2021 | | 36 | 144 |
| 2 | Abby Robbins | Sr | Farmington | 2021 | | 37 | 144 |
| 4 | Makenzie Goswick | Sr | Joplin | 2015 | | 35 | 141 |
| 4 | Kayla Patricia Ulrich | Jr | Sullivan | 2021 | | 37 | 141 |
| 4 | Keira Chrisco | Sr | Rolla | 2021 | | 40 | 141 |
| 7 | Courtney Swink | Sr | Farmington | 2021 | | 37 | 138 |
| 8 | Riley Branson | Sr | Sullivan | 2021 | | 37 | 137 |
| 9 | Angelia Davis | Jr | Farmington | 2021 | | 37 | 135 |
| 10 | Lillian Grace Knesel | Sr | Marquette | 2017 | | 32 | 132 |
| 10 | Peyton Hawkins | Jr | Webb City | 2020 | | 33 | 132 |
| 10 | Sophia Ann-Marie Weirich | Sr | Sullivan | 2021 | | 37 | 132 |
| 13 | Emily Crane | Sr | Troy Buchanan | 2011 | | 33 | 131 |
| 14 | Peyton Corrigan | Sr | Holden | 2018 | | 32 | 130 |
| 15 | Kaesha George | Jr | Monett | 2018 | | 32 | 128 |
| 15 | Addison Purvis | Jr | Sullivan | 2018 | | 33 | 128 |
| 15 | Madison White | Sr | Rock Bridge | 2019 | | 35 | 128 |
| 18 | Emma Welch | Jr | Webb City | 2020 | | 33 | 127 |
| 19 | Alexis Van Nostrand | Sr | Palmyra | 2012 | | 31 | 126 |
| 19 | Evvie Rae Blankenship | Fr | Sullivan | 2021 | | 37 | 126 |
| 21 | Maddison Brown | Sr | Mt. Vernon | 2016 | | 32 | 125 |
| 21 | Maddi Coones | Sr | Monett | 2018 | | 32 | 125 |
| 21 | Kamryn Lohden | Sr | Sullivan | 2018 | | 33 | 125 |
| 21 | Haidyn Berry | Sr | Webb City | 2020 | | 33 | 125 |
| 25 | Jennifer Mills | Sr | Centralia | 2011 | | 31 | 124 |
| 25 | Sammey Clara Bunch | Sr | Fatima | 2015 | | 32 | 124 |
| 25 | Kinsley Stewart | Jr | Joplin | 2015 | | 35 | 124 |
| 25 | Karli Allen | Sr | Fox | 2015 | | 32 | 124 |
| 25 | Katelin Ann Kurima | Sr | Monett | 2017 | | 32 | 124 |
| 25 | Bridgette Swinford | Jr | Chaffee | 2017 | | 31 | 124 |
| 25 | Maggie Klover | Sr | Holden | 2018 | | 31 | 124 |
| 32 | Bailee Bryant | Sr | Holden | 2018 | | 32 | 123 |
| 33 | Hanna Nicole Johanning | Jr | Sullivan | 2019 | | 32 | 122 |
| 34 | Mikaela Cox | Sr | Joplin | 2015 | | 133 | 35 |
| 34 | Tamarah Mascher | Sr | Joplin | 2015 | | 129 | 35 |