| Rank | K | Student | School | Opponent | Date | |
| 1 | 12 | Hailey Presley | Marion C. Early | Spokane | 4/3/2023 | |
| 2 | 10 | Callie Weant | Weaubleau | Dadeville | 8/25/2009 | |
| 2 | 10 | Tressa Hughes | Dixon | Newburg HS | 8/18/2017 | |
| 2 | 10 | Reese Elisabeth Plattner | Archie | Archie | 3/20/2021 | vs Adrian |
| 5 | 9 | Loren Stark | Tina-Avalon | Breckenridge | 9/16/2003 | (9 BF) |
| 5 | 9 | Katelyn Tolle | Bevier | Keytesville | 9/15/2008 | |
| 5 | 9 | Allison Ehrlich | John F. Kennedy High School | Soldan International Studies | 10/8/2008 | |
| 5 | 9 | Callie Weant | Weaubleau | Macks Creek | 9/28/2009 | (9 BF) |
| 5 | 9 | Aleah Paxton | Lincoln | | 4/6/2018 | 9 Batters Faced |
| 5 | 9 | Izabelle Erickson | Reeds Spring | | 9/24/2019 | vs. Aurora |
| 5 | 9 | Reagan Robinson | Stewartsville | | 9/3/2019 | |
| 5 | 9 | Natalie Wilks | Sparta | Sparta | 3/22/2021 | |
| 5 | 9 | Natalie Wilks | Sparta | Seymour | 3/22/2021 | |
| 5 | 9 | Alexis Parson | Twin Rivers | Puxico | 3/18/2024 | |
| 15 | 8 | Kinlee Cochran | Iberia | Dixon | 9/14/2022 | |
| 15 | 8 | Kinlee Cochran | Iberia | Richland | 9/1/2023 | |
| 15 | 8 | Hailey Presley | Marion C. Early | Hurley | 3/22/2023 | |
| 15 | 8 | Haley Madewell | Marion C. Early | Hurley | 3/21/2023 | |
| 15 | 8 | Abigail Lay | Highland | Knox County | 10/10/2024 | |
| 15 | 8 | Kinlee Cochran | Iberia | Laquey | 9/27/2024 | |
| 15 | 8 | Kinlee Cochran | Iberia | Tuscumbia | 10/3/2024 | |
| 22 | 7 | Karli Mae Johnson | Jackson | Van Buren | 9/4/2020 | Perfect Game |
| 22 | 7 | Ashlyn Evan Dawes | Jackson | Van Buren | 9/2/2022 | |