| Rank | Student | School | Years | | 2B | G | AVG |
| 1 | Ali Raley | Pierce City | 2014-2017 | | 66 | 100 | .660 |
| 2 | Madison McKinney | Norborne | 2012-2015 | | 61 | 96 | .635 |
| 3 | Tabitha Francka | Marion C. Early | 2012-2015 | | 54 | 95 | .568 |
| 4 | Riley Wilkinson | Marshall | 2021-2024 | | 52 | 93 | .559 |
| 5 | Carli Layne Cook | Plato | 2021-2024 | | 57 | 104 | .548 |
| 6 | Marin Whorton | Ozark | 1993-1996 | | 45 | 87 | .517 |
| 7 | Kayla Patricia Ulrich | Sullivan | 2019-2022 | | 68 | 132 | .515 |
| 8 | Sarah Roth | Northwest (Cedar Hill) | 2017-2020 | | 58 | 113 | .513 |
| 9 | Cali Coombs | Russellville | 2019-2022 | | 59 | 115 | .513 |
| 10 | Kaetlyn Reece Danley | Holcomb | 2020-2023 | | 63 | 126 | .500 |
| 10 | Sara Harvey | Staley | 2010-2013 | | 49 | 98 | .500 |
| 12 | Emma Nichols | Hillsboro | 2015-2018 | | 57 | 117 | .487 |
| 13 | Kylie Marie Helm | McDonald County | 2015-2018 | | 54 | 112 | .482 |
| 14 | Madison Marie Uptegrove | Father Tolton Regional Catholic | 2020-2023 | | 63 | 131 | .481 |
| 15 | Kali Nelson | Dixon | 2012-2015 | | 47 | 98 | .480 |
| 16 | Cheyenne Bieber | Mt. Vernon | 2021-2024 | | 65 | 138 | .471 |
| 17 | Hailey Presley | Marion C. Early | 2020-2023 | | 56 | 123 | .455 |
| 18 | Brittany Smith | Seckman | 2006-2010 | | 45 | 99 | .455 |
| 19 | Sammey Clara Bunch | Fatima | 2012-2015 | | 49 | 108 | .454 |
| 20 | Addison Purvis | Sullivan | 2016-2019 | | 53 | 117 | .453 |
| 21 | Mac Lane Morgan | Sherwood | 2017-2020 | | 45 | 100 | .450 |
| 22 | Blaire Riley | Kelly | 2021-2024 | | 54 | 122 | .443 |
| 23 | Sophia Gentry | Bishop LeBlond | 2010-2013 | | 49 | 111 | .441 |
| 24 | Micah Elizabeth Scharff | Ladue Horton Watkins | 2007-2010 | | 35 | 80 | .438 |
| 25 | Tara Verkuilen | Schuyler County | 2004-2007 | | 33 | 76 | .434 |
| 26 | Alexis Ralls | Notre Dame (Cape Girardeau) | 2005-2008 | | 28 | 65 | .431 |
| 27 | Payton Miller | Highland | 2019-2022 | | 42 | 98 | .429 |
| 28 | Brooke Huitt | Lathrop | 2015-2018 | | 47 | 113 | .416 |
| 29 | Maleigh Elizabeth Lemings | Holcomb | 2020-2023 | | 51 | 127 | .402 |
| 30 | Hannah Marie Cox | Sullivan | 2016-2019 | | 47 | 118 | .398 |
| 31 | Paige Eddington | Doniphan | 2014-2017 | | 53 | 134 | .396 |
| 32 | Hanna Nicole Johanning | Sullivan | 2017-2020 | | 46 | 117 | .393 |
| 33 | Rae Downing | Mt. Vernon | 2021-2024 | | 55 | 141 | .390 |
| 34 | Maci Moore | Trenton | 2018-2021 | | 41 | 106 | .387 |
| 35 | Karsyn Brooke | Mansfield | 2015-2018 | | 50 | 132 | .379 |
| 36 | Morgan Hull | Mt. Vernon | 2013-2016 | | 42 | 111 | .378 |
| 37 | Kirsten Dunn | Chillicothe | 2019-2022 | | 40 | 106 | .377 |
| 38 | Madelyn Stichling | Northwest (Cedar Hill) | 2018-2021 | | 43 | 114 | .377 |