| Rank | Student | Grade | School | Year | | K | IP | AVG |
| 1 | Abby Summers | Sr | West Platte | 2014 | | 382 | 156.1 | 17.104 |
| 2 | Katelyn Tolle | Sr | Bevier | 2009 | | 311 | 133 | 16.368 |
| 3 | Jacquelyn Bishop | Sr | Kirksville | 2009 | | 380 | 164.1 | 16.187 |
| 4 | Izabelle Erickson | Sr | Reeds Spring | 2019 | | 223 | 100.1 | 15.558 |
| 5 | Kacey Marshall | Sr | New Franklin | 1989 | | 237 | 108 | 15.361 |
| 6 | Jaylynn J Brown | So | Centralia | 2024 | | 331 | 154 | 15.045 |
| 7 | Lauren Delaney | Jr | Helias Catholic | 2004 | | 294 | 137 | 15.022 |
| 8 | Katelyn Tolle | So | Bevier | 2007 | | 278 | 130.1 | 14.931 |
| 9 | Emily Fowler-Cornfeld | Sr | Clayton | 2004 | | 242 | 114 | 14.860 |
| 10 | Lauren Delaney | Sr | Helias Catholic | 2005 | | 338 | 160 | 14.788 |
| 11 | Katie Shockley | Jr | Crocker | 2009 | | 233 | 112 | 14.563 |
| 12 | Emily Fowler-Cornfeld | Jr | Clayton | 2003 | | 247 | 119 | 14.529 |
| 13 | Zoe Martin | Sr | Sacred Heart | 2023 | | 250 | 121 | 14.463 |
| 14 | Maddy Colin | Jr | College Heights Christian | 2022 | | 270 | 141 | 13.404 |
| 15 | Hailey Presley | Sr | Marion C. Early | 2023 | | 376 | 205.1 | 12.818 |
| 16 | Olivia Grace Emery | Sr | Neosho | 2025 | | 318 | 181 | 12.298 |
| 17 | Hailey Presley | Jr | Marion C. Early | 2022 | | 265 | 188 | 9.867 |
| 18 | Maddy Colin | Jr | College Heights Christian | 2022 | | 270 | 111117777 | .000 |