| Rank | Student | School | Opponent | Date | | Inn | SO |
| 1 | Conner Fletcher | Meadville | Bevier | 10/12/2020 | | 6 | 20 |
| 2 | Thomas Smith | University Academy Charter | Northeast (Kansas City) | 4/16/2026 | | 55 | 19 |
| 2 | Thomas Smith | University Academy Charter | Northeast (Kansas City) | 4/16/2026 | | 5 | 19 |
| 4 | Wyatt Brown | Affton | Bishop DuBourg | 3/24/2021 | | 6 | 18 |
| 5 | Travis Hulsey | Hancock | Grandview (Hillsboro) | 4/17/2017 | | 6 | 17 |
| 5 | Hunter Lane | Macks Creek | | 4/26/2019 | | 6.2 | 17 |
| 5 | Jorden Eaton | Clearwater | Dexter | 3/20/2021 | | 6.2 | 17 |
| 5 | Jorden Eaton | Clearwater | Dexter | 3/20/2021 | | 6.2 | 17 |
| 5 | Tristan Hunter | Forsyth | Fair Grove | 5/15/2024 | | 6.1 | 17 |
| 5 | Ean Bone | Bismarck | Bourbon | 4/20/2026 | | 6.2 | 17 |
| 11 | Shane Mochel | Windsor | Wellington-Napoleon | 4/16/2004 | | 6 | 16 |
| 11 | Joseph Kassanavoid | Lawson | North Platte | 4/5/2006 | | 6 | 16 |
| 11 | Brandon Holland | Louisiana | Montgomery County | 4/6/2013 | | 6 | 16 |
| 11 | Gage Mashburn | Macks Creek | | 4/10/2018 | | 6.1 | 16 |
| 11 | Jacob W Davis | Northeast (Cairo) | | 4/14/2018 | | 6 | 16 |
| 11 | Garrett Hester | Adrian | | 4/16/2019 | | 6 | 16 |
| 11 | Bryce Morgan | Kelly | Charleston | 5/1/2021 | | 6 | 16 |
| 18 | Matt Skyles | Mansfield | Forsyth | 5/18/1995 | | 6.2 | 15 |
| 18 | Kaleb Cooper | Walnut Grove | Humansville | 5/12/2006 | | 5 | 15 |
| 18 | Logan Holthaus | Winona | Licking | 8/26/2008 | | 6 | 15 |
| 18 | Kendal Littleton | Keytesville | Macon County | 8/26/2008 | | 5 | 15 |
| 18 | Kendal Fay | Clearwater | Hurley | 8/29/2010 | | 5 | 15 |
| 18 | Josh Moore | Pacific | | 4/29/2011 | | 6 | 15 |
| 18 | Jacob Daniel Weirich | Jefferson City | McCracken County, KY | 5/23/2017 | | 5.2 | 15 |
| 18 | Jaden Thacker | Winona | Eminence | 4/19/2021 | | 6 | 15 |
| 18 | Payton Green | El Dorado Springs | Sherwood | 4/18/2022 | | 6.2 | 15 |
| 18 | Dalton Forck | Kelly | Kennett | 3/16/2024 | | 6 | 15 |
| 18 | Preston Listerud | Osceola | Climax Springs | 4/18/2025 | | 6.1 | 15 |
| 18 | Alex Lakota Terrill | Summersville | Winona | 9/9/2025 | | 6 | 15 |
| 30 | Matt Skyles | Mansfield | Hartville | 5/17/1996 | | 5 | 14 |
| 30 | Chris Mackey | Springfield Catholic | Stockton | 3/31/2004 | | 5 | 14 |
| 30 | Derrick Morris | Walnut Grove | Halfway | 4/4/2007 | | 5 | 14 |
| 30 | Josh White | Stoutland | Santa Fe | 5/30/2007 | | 5.2 | 14 |
| 30 | Wyatt Baker Sparks | Aurora | | 3/19/2018 | | 5 | 14 |
| 30 | Hunter Lane | Macks Creek | | 3/21/2019 | | 5 | 14 |
| 30 | Logan Vincent Bruns | Jackson | Fredericktown | 3/20/2021 | No - Hitter | 5 | 14 |
| 30 | Dylan Cole | Bismarck | Bourbon | 4/19/2021 | | 6 | 14 |
| 30 | Zach Craig | Summersville | Eminence | 4/12/2022 | | 5 | 14 |
| 39 | Dalton Hartman | Summersville | Winona | 10/2/2023 | | 5 | 13 |
| 39 | Gavin Mullins | Kingsville | Leeton | 5/9/2024 | | 423 | 13 |
| 39 | Gavin Mullins | Kingsville | Drexel | 4/22/2025 | | 5 | 13 |
| 39 | Marcellus Brooks Goudeau | Raytown South | Washington (KCK) | 4/6/2026 | | 6 | 13 |