| Rank | Student | School | Years | | G | R |
| 1 | Jake Welch | Bernie | 2007-2010 | | 94 | 173 |
| 2 | Jake Whitesides | Hickman | 1997-2000 | | 100 | 167 |
| 2 | Blake DeWitt | Sikeston | 2001-2004 | | 107 | 167 |
| 4 | Mason Adams | Portageville | 2020-2024 | | 143 | 159 |
| 5 | Nathan Geile | Valle Catholic | 2007-2010 | | 116 | 157 |
| 6 | Connor S Basler | Valle Catholic | 2012-2015 | | 116 | 150 |
| 7 | Johnny Eierman | Warsaw | 2006-2010 | | 79 | 143 |
| 8 | Austin Schmitt | Valley Park | 2014-2017 | | 109 | 140 |
| 9 | Justin Eiken | Blair Oaks | 2006-2009 | | 87 | 139 |
| 10 | Chase Morris | Southern Boone | 2020-2023 | | 130 | 133 |
| 11 | Jared Johnson | Whitfield | 1991-1994 | | 100 | 132 |
| 11 | Jeff Melton | Herculaneum | 2000-2003 | | 106 | 132 |
| 11 | Kendall Fay | Clearwater | 2007-2010 | | 96 | 132 |
| 14 | Ryan Rallo | Christian Brothers College | 1996-1999 | | 97 | 131 |
| 14 | Robert Mitchell | Herculaneum | 1998-2001 | | 105 | 131 |