| Rank | Total | Student | School | Opponent | Date | |
| 1 | 6 | Amanda Fitzwilliam | Oakville | | 9/21/2017 | |
| 1 | 6 | Samantha Waldron | Lindbergh | | 9/5/2018 | Pattonville |
| 1 | 6 | Elena Lara | Arcadia Valley | Clearwater | 3/27/2023 | |
| 1 | 6 | Alexis Hagler | Winona | Richland (Essex) | 4/30/2024 | |
| 5 | 5 | Casey Little | Conway | Gainesville | 9/10/1988 | |
| 5 | 5 | Angela Hasty | O'Hara | Harrisonville | 5/3/1994 | |
| 5 | 5 | Jenny Butler | Mid-Buchanan | Smithville | 9/6/1994 | |
| 5 | 5 | Erin Helsel | Mid-Buchanan | Penney | 9/29/1994 | |
| 5 | 5 | Shanin Kelley | Mid-Buchanan | West Platte | 9/28/1996 | |
| 5 | 5 | Annie Harmon | Seckman | Mehlville | 8/26/1998 | |
| 5 | 5 | Joy Puricelli | Lutheran South | Mehlville | 9/10/1998 | |
| 5 | 5 | Jami Perryman | Conway | Gainesville | 10/22/1998 | at Hartville |
| 5 | 5 | Casey Little | Conway | Gainesville | 10/22/1998 | at Hartville |
| 5 | 5 | Bonny Wheeler | Union Star | Stewartsville | 10/2/1999 | |
| 5 | 5 | Nikki Hamm | Mid-Buchanan | Lathrop | 9/20/2001 | |
| 5 | 5 | Heather Robey | Central (New Madrid County) | Blytheville (Ark.) | 4/2/2003 | |
| 5 | 5 | Autumn Walker | Central (New Madrid County) | Blytheville (Ark.) | 4/2/2003 | |
| 5 | 5 | Emily Speorl | Reeds Spring | Central (Springfield) | 9/9/2003 | |
| 5 | 5 | Debbie Cunningham | Webster Groves | Mehlville | 9/21/2004 | |
| 5 | 5 | Kelsey Biggs | Seckman | Parkway West | 9/17/2008 | |
| 5 | 5 | Courtney Lee deRonde | Nixa | Parkview | 8/24/2009 | (3 inn.) |
| 5 | 5 | Destinee Greathouse | Sarcoxie | Billings | 9/25/2009 | |
| 5 | 5 | Brittany Gotthardt | Ft. Zumwalt East | Warrenton | 8/28/2010 | |
| 5 | 5 | Lindsay Schaefer | Seckman | Mehlville | 8/30/2011 | |
| 5 | 5 | MaKay Belt | La Plata | Linn County | 9/23/2011 | |
| 5 | 5 | Kelli Koehler | Weaubleau | Hermitage | 8/28/2012 | |
| 5 | 5 | Cassidy Diebold | Holt | Sullivan | 8/30/2012 | |
| 5 | 5 | Alyssa D Lilly | Holt | Sullivan | 8/30/2012 | |
| 5 | 5 | Olivia Denslow | Kirksville | Boonville | 9/6/2012 | |
| 5 | 5 | Sara Harvey | Staley | Liberty | 9/7/2012 | |
| 5 | 5 | Katlin A Carr | Oak Grove | Lafayette County | 9/24/2012 | |
| 5 | 5 | Audrey Glenski | Bishop LeBlond | Polo | 9/7/2013 | |
| 5 | 5 | Sammey Clara Bunch | Fatima | Pleasant Hope | 10/25/2014 | |
| 5 | 5 | Hannah D Criswell | Kennett | Crest Ridge | 5/17/2014 | |
| 5 | 5 | Meagan E Mccorkell | Seckman | | 8/27/2016 | vs. Affton |
| 5 | 5 | Abigail King | Christian | Ft. Zumwalt East | 9/22/2017 | |
| 5 | 5 | Kassidy Watts | Sparta | | 3/20/2018 | |
| 5 | 5 | Maris Ollison | Versailles | | 9/30/2019 | |
| 5 | 5 | Alaney Moore | Kelly | | 10/7/2019 | vs. Doniphan |
| 5 | 5 | Preslee Jo Sunderland | Fayette | Salisbury | 10/5/2021 | |
| 5 | 5 | Kylie Walker | Senath-Hornersville | Central (New Madrid County) | 3/18/2023 | |
| 5 | 5 | Abigail Jamros | Seneca | Aurora | 10/12/2023 | |
| 43 | 4 | Anne Nottebrok | Parkway Central | | 1/1/1981 | Class 3A-4A |
| 43 | 4 | Elisha Bonnot | Fatima | | 1/1/1996 | Class 2A-3A |
| 43 | 4 | Darby Pruett | Naylor | Silex | 10/1/2012 | Class 1 |
| 43 | 4 | Kelly Ivy | Kelly | | 9/6/2019 | |
| 43 | 4 | Kendyl Stuckey | Kelly | | 9/14/2019 | vs. Eldon |
| 43 | 4 | Elly Pattengill | Kelly | | 9/14/2019 | vs. Eldon |
| 43 | 4 | Kelly Ivy | Kelly | | 9/28/2019 | |
| 43 | 4 | | Chillicothe | Savannah | 9/25/2021 | |
| 43 | 4 | Kinlei Boley | Chillicothe | Savannah | 9/25/2021 | |
| 43 | 4 | | Chillicothe | South Harrison | 9/11/2021 | |
| 43 | 4 | Sophia Luetticke | Chillicothe | Cameron | 9/14/2021 | |
| 43 | 4 | Sophia Luetticke | Chillicothe | South Harrison | 9/11/2021 | |
| 43 | 4 | Kirsten Dunn | Chillicothe | Kirksville | 9/11/2021 | |
| 43 | 4 | Hannah Collens | Kingsville | Windsor | 4/5/2024 | |
| 43 | 4 | Jenna Murkin | Kingsville | Windsor | 4/5/2024 | |
| 58 | 3 | Jessica Vogel & Karmin Hawkins | Lutheran South | | 1/1/2002 | Class 3 |
| 58 | 3 | Alesa K Frey & Natalie Wheeler | Brookfield | | 1/1/2012 | Class 2 |
| 58 | 3 | Kiersten Nixon | Troy Buchanan | Blue Springs South | 10/1/2016 | Class 4 |