| Rank | Student | School | Years | | R | G | AVG |
| 1 | Elle Smith | Blue Springs South | 2018-2021 | | 120 | 35 | 3.429 |
| 2 | Kassidy Watts | Sparta | 2015-2018 | | 141 | 66 | 2.136 |
| 3 | Zoe Brittan | Valley Park | 2004-2006 | | 154 | 74 | 2.081 |
| 4 | Maleigh Elizabeth Lemings | Holcomb | 2020-2023 | | 243 | 127 | 1.913 |
| 5 | Bailey Burns | Puxico | 2015-2018 | | 153 | 80 | 1.913 |
| 6 | Shelly Jermain | Jefferson | 1986-1989 | | 109 | 59 | 1.847 |
| 7 | Regan Nash | North Platte | 2011-2014 | | 164 | 94 | 1.745 |
| 8 | Adrienne Compton | Hancock | 2012-2015 | | 122 | 70 | 1.743 |
| 9 | Kloee Williamson | McAuley Catholic | 2020-2023 | | 151 | 88 | 1.716 |
| 10 | Alane Cordray | Mt. Vernon | 2014-2017 | | 144 | 84 | 1.714 |
| 11 | Dava Nelson | North Harrison | 1990-1993 | | 112 | 66 | 1.697 |
| 12 | Paige Eddington | Doniphan | 2014-2017 | | 225 | 134 | 1.679 |
| 13 | Lauren Taylor | Marion C. Early | 2019-2022 | | 156 | 96 | 1.625 |
| 14 | Tabitha Francka | Marion C. Early | 2012-2015 | | 152 | 95 | 1.600 |
| 15 | Sophia Luetticke | Chillicothe | 2018-2021 | | 150 | 94 | 1.596 |
| 16 | Maddison Brown | Mt. Vernon | 2013-2016 | | 158 | 100 | 1.580 |
| 17 | Ragan Blinzler | Pierce City | 2014-2017 | | 156 | 99 | 1.576 |
| 18 | Olivia Jo Pfeifer | Hannibal | 2014-2017 | | 148 | 95 | 1.558 |
| 19 | Sammey Clara Bunch | Fatima | 2012-2015 | | 167 | 108 | 1.546 |
| 20 | Valerie Teter | Bevier | 2003-2006 | | 146 | 99 | 1.475 |
| 21 | Madison Marie Uptegrove | Father Tolton Regional Catholic | 2020-2023 | | 188 | 131 | 1.435 |
| 22 | Halle Gooch | Clearwater | 2014-2017 | | 133 | 93 | 1.430 |
| 23 | Sydney Miller | Willow Springs | 2015-2018 | | 150 | 105 | 1.429 |
| 24 | Emily Crane | Troy Buchanan | 2008-2011 | | 168 | 118 | 1.424 |
| 25 | Cali Coombs | Russellville | 2019-2022 | | 163 | 115 | 1.417 |
| 26 | Sarah Roth | Northwest (Cedar Hill) | 2017-2020 | | 160 | 113 | 1.416 |
| 27 | Livia Dumm | Jasper | 2021-2023 | | 158 | 114 | 1.386 |
| 28 | Maris Ollison | Versailles | 2018-2021 | | 141 | 103 | 1.369 |
| 29 | Abigail Rickermann | Festus | 2016-2019 | | 138 | 102 | 1.353 |
| 30 | Alexi Sanchez | Northwest (Cedar Hill) | 2018-2021 | | 141 | 106 | 1.330 |
| 31 | Hailey Presley | Marion C. Early | 2020-2023 | | 160 | 123 | 1.301 |
| 32 | Audrey Glenski | North Platte | 2011-2014 | | 132 | 103 | 1.282 |
| 33 | Karsyn Brooke | Mansfield | 2015-2018 | | 159 | 132 | 1.205 |
| 34 | Maggie Painter | Marion C. Early | 2020-2023 | | 114 | 118 | 0.966 |