| Rank | Student | School | Years | | RBI | G | Total |
| 1 | Madison McKinney | Norborne | 2012-2015 | | 220 | 96 | 2.292 |
| 2 | Adrienne Compton | Hancock | 2012-2015 | | 130 | 70 | 1.857 |
| 3 | Katie Wood | Norborne | 2013-2016 | | 173 | 94 | 1.840 |
| 4 | Sydney McKinney | Norborne | 2014-2017 | | 180 | 98 | 1.837 |
| 5 | Mac Lane Morgan | Sherwood | 2017-2020 | | 177 | 100 | 1.770 |
| 6 | Shelly Jermain | Jefferson | 1986-1989 | | 101 | 59 | 1.712 |
| 7 | Ali Raley | Pierce City | 2014-2017 | | 171 | 100 | 1.710 |
| 8 | Madison Norman | Tipton | 2010-2013 | | 140 | 82 | 1.707 |
| 9 | Elizabeth Dains | Valley Park | 2002-2005 | | 142 | 85 | 1.671 |
| 10 | Hadley Wilson | Kennett | 2020-2023 | | 199 | 123 | 1.618 |
| 11 | Criswell, Hannah | Kennett | 2013-2016 | | 163 | 102 | 1.598 |
| 12 | Katlyn Kasubke | St. Dominic | 2011-2014 | | 173 | 110 | 1.573 |
| 13 | Micah Elizabeth Scharff | Ladue Horton Watkins | 2007-2010 | | 123 | 80 | 1.538 |
| 14 | Michelle Madden | Jefferson | 1986-1989 | | 86 | 56 | 1.536 |
| 15 | Paige Eddington | Doniphan | 2014-2017 | | 200 | 134 | 1.493 |
| 16 | Madison Marie Uptegrove | Father Tolton Regional Catholic | 2020-2023 | | 192 | 131 | 1.466 |
| 17 | Morgan Hull | Mt. Vernon | 2013-2016 | | 161 | 111 | 1.450 |
| 18 | Hannah Marie Cox | Sullivan | 2016-2019 | | 170 | 118 | 1.441 |
| 19 | Abigail King | Christian | 2014-2017 | | 121 | 84 | 1.440 |
| 20 | Zoe Brittan | Valley Park | 2004-2006 | | 106 | 74 | 1.432 |
| 21 | Sharon Bax | Fatima | 1982-1985 | | 92 | 66 | 1.394 |
| 21 | Dava Nelson | North Harrison | 1990-1993 | | 92 | 66 | 1.394 |
| 23 | Addison Purvis | Sullivan | 2016-2019 | | 163 | 117 | 1.393 |
| 24 | Hailey Presley | Marion C. Early | 2020-2023 | | 170 | 123 | 1.382 |
| 25 | Shelby Ann-Renee Webster | Camdenton | 2015-2018 | | 140 | 102 | 1.373 |
| 26 | Brianna Isabelle Lore | Sullivan | 2008-2011 | | 139 | 103 | 1.350 |
| 26 | Brianna Isabelle Lore | Sullivan | 2008-2011 | | 139 | 103 | 1.350 |
| 28 | Halle Gooch | Clearwater | 2014-2017 | | 124 | 93 | 1.333 |
| 29 | Maci Moore | Trenton | 2018-2021 | | 138 | 106 | 1.302 |
| 30 | Sierra Culver | Kearney | 2016-2019 | | 145 | 112 | 1.295 |
| 31 | Kylie Marie Helm | McDonald County | 2015-2018 | | 142 | 112 | 1.268 |
| 32 | Kinlei Boley | Chillicothe | 2019-2022 | | 130 | 104 | 1.250 |
| 33 | Kelsey Claire Lenox | Marquette | 2014-2017 | | 128 | 104 | 1.231 |
| 34 | Karsyn Brooke | Mansfield | 2015-2018 | | 160 | 132 | 1.212 |
| 35 | Marissa Peek | Holt | 2016-2019 | | 139 | 117 | 1.188 |
| 36 | Emma Nichols | Hillsboro | 2015-2018 | | 138 | 117 | 1.179 |
| 37 | Salem Croy | Trenton | 2015-2018 | | 128 | 109 | 1.174 |
| 38 | Hanna Nicole Johanning | Sullivan | 2017-2020 | | 136 | 117 | 1.162 |
| 39 | Kayla Patricia Ulrich | Sullivan | 2019-2022 | | 153 | 132 | 1.159 |
| 40 | Keira Chrisco | Rolla | 2018-2021 | | 123 | 116 | 1.060 |
| 41 | Makenzie Marie Gladney | Elsberry | 2019-2022 | | 85 | 95 | 0.895 |