| Rank | Student | School | Years | | G | HR |
| 1 | Madison Marie Uptegrove | Father Tolton Regional Catholic | 2020-2023 | | 131 | 48 |
| 2 | Mac Lane Morgan | Sherwood | 2017-2020 | | 100 | 47 |
| 3 | Paige Eddington | Doniphan | 2014-2017 | | 134 | 43 |
| 3 | Abby Carol Hay | Rock Bridge | 2022-2023 | | 122 | 43 |
| 5 | Katie Ann Chester | Liberty North | 2018-2021 | | 114 | 42 |
| 6 | Taylor Hamilton | Cameron | 2011-2014 | | 104 | 41 |
| 6 | Anastasia Grace Mueller | Pacific | 2016-2019 | | 96 | 41 |
| 8 | Nicole Hudson | Webb City | 2005-2008 | | 117 | 40 |
| 9 | Addison Purvis | Sullivan | 2016-2019 | | 117 | 36 |
| 9 | Hannah Marie Cox | Sullivan | 2016-2019 | | 118 | 36 |
| 9 | Kara Kaye Daly | Jefferson City | 2017-2020 | | 104 | 36 |
| 12 | Maleigh Elizabeth Lemings | Holcomb | 2020-2023 | | 127 | 35 |
| 13 | Valerie Teter | Bevier | 2003-2006 | | 99 | 34 |
| 13 | Ashley Ellis | Fox | 2012-2015 | | 113 | 34 |
| 13 | Carlie Sanders | Hillsboro | 2014-2017 | | 107 | 34 |
| 16 | Sierra Culver | Kearney | 2016-2019 | | 112 | 31 |
| 17 | Shelby Ann-Renee Webster | Camdenton | 2015-2018 | | 102 | 30 |
| 18 | Jessica Damico | Pacific | 2007-2010 | | 94 | 29 |
| 18 | Jordan Shewmaker | Buffalo | 2010-2013 | | 98 | 29 |
| 18 | Marissa Peek | Holt | 2016-2019 | | 117 | 29 |
| 18 | Maci Moore | Trenton | 2018-2021 | | 106 | 29 |
| 18 | Kayla Patricia Ulrich | Sullivan | 2019-2022 | | 132 | 29 |
| 23 | Maris Ollison | Versailles | 2018-2021 | | 103 | 28 |
| 24 | Caitlin Chapin | Ozark | 2005-2008 | | 120 | 27 |
| 24 | Kami Holt | Republic | 2013-2016 | | 108 | 27 |
| 24 | Emma Nichols | Hillsboro | 2015-2018 | | 117 | 27 |
| 24 | Erin McPike | East Buchanan | 2017-2020 | | 91 | 27 |
| 28 | Dana M Graves | Weaubleau | 2009-2012 | | 109 | 26 |
| 28 | Molly Carter | Hickman | 2011-2014 | | 105 | 26 |
| 30 | Ashley Fleming | Silex | 2004-2008 | | 100 | 25 |
| 30 | Ali Raley | Pierce City | 2014-2017 | | 100 | 25 |
| 32 | Kylie DeClue | Park Hill South | 2012-2015 | | 111 | 24 |
| 32 | Karsyn Brooke | Mansfield | 2015-2018 | | 132 | 24 |
| 34 | Kreslee Jo Ketcham | Neosho | 2005-2008 | | 111 | 23 |
| 34 | Adrienne Compton | Hancock | 2012-2015 | | 70 | 23 |
| 34 | Hanna Nicole Johanning | Sullivan | 2017-2020 | | 117 | 23 |
| 37 | Aubrey Christine Brown | Raymore-Peculiar | 2016-2019 | | 114 | 22 |
| 37 | Paige McCord | Hallsville | 2018-2021 | | 89 | 22 |
| 39 | Savannah Fisher | Hallsville | 2011-2014 | | 90 | 21 |
| 39 | Criswell, Hannah | Kennett | 2013-2016 | | 102 | 21 |
| 39 | Marissa Dawn Austene | Hallsville | 2020-2023 | | 101 | 21 |
| 39 | Meredith Hope Blakemore | Hallsville | 2020-2023 | | 95 | 21 |
| 39 | Hailey Presley | Marion C. Early | 2020-2023 | | 123 | 21 |
| 39 | Kylie Walker | Senath-Hornersville | 2021-2022 | | 32 | 21 |
| 45 | Brittany Nimmo | Ozark | 2010-2013 | | 120 | 20 |
| 46 | Salem Croy | Trenton | 2015-2018 | | 109 | 19 |
| 47 | Lexi Whitaker | Trenton | 2017-2020 | | 103 | 18 |
| 48 | Bailey Brumley | Blue Springs South | 2018-2021 | | 118 | 17 |
| 49 | Cindy Wolf | St. Charles | 1977-1979 | | 56 | 15 |
| 49 | | Montgomery County | 2018-2021 | | 87 | 15 |
| 49 | | Montgomery County | 2018-2021 | | 87 | 15 |
| 49 | Taylor Blehm | Marion C. Early | 2020-2023 | | 116 | 15 |