| Rank | Student | Grade | School | Year | | YDS | G | Total |
| 1 | Steven Willhite | Sr | Pattonsburg | 2019 | | 6175 | 12 | 514.58 |
| 2 | Zane Reed | Jr | Pattonsburg | 2020 | | 4794 | 10 | 479.40 |
| 3 | Jordan Webb | Jr | Union | 2007 | | 4941 | 11 | 449.18 |
| 4 | Kory Faulkner | Sr | Ste. Genevieve | 2008 | | 4954 | 12 | 412.83 |
| 5 | T.J. Moe | Sr | Ft. Zumwalt West | 2008 | | 4586 | 12 | 382.17 |
| 6 | Koby Reynolds | Jr | North Nodaway | 2014 | | 4583 | 12 | 381.92 |
| 7 | Mack J Anderson | Sr | Southwest (Livingston County) | 2019 | | 4796 | 13 | 368.92 |
| 8 | Cooper Callis | Sr | Jackson | 2017 | 368.18 per game | 4050 | 11 | 368.18 |
| 9 | Jacob Beckmeyer | Sr | Wellington-Napoleon | 2013 | | 4755 | 13 | 365.77 |
| 10 | Dylan Jacob Hair | Sr | Blair Oaks | 2022 | | 5037 | 14 | 359.79 |
| 11 | T.J. Moe | Jr | Ft. Zumwalt West | 2007 | | 3823 | 11 | 347.55 |
| 12 | Zane Jacoby | Sr | Westran | 2014 | | 5172 | 15 | 344.80 |
| 13 | Jordan Webb | Sr | Union | 2008 | | 4128 | 12 | 344.00 |
| 14 | Jeff Handy | Sr | Blue Springs | 1989 | | 3411 | 10 | 341.10 |
| 15 | Cameron Coffman | Sr | Raymore-Peculiar | 2010 | | 3739 | 11 | 339.91 |
| 16 | Drew Hare | Jr | Ft. Zumwalt West | 2010 | | 4262 | 13 | 327.85 |
| 17 | Jacob Coffey | Jr | Drexel | 2021 | | 4094 | 13 | 314.92 |
| 18 | Eric Humes | Sr | West Platte | 2005 | | 4399 | 14 | 314.21 |
| 19 | Kellen Overstreet | Sr | Penney | 2014 | | 4344 | 14 | 310.29 |
| 20 | Sean Ransburg | Sr | Harrisonville | 2007 | | 4233 | 14 | 302.36 |
| 21 | Javan Rae Noyes | Sr | Mid-Buchanan | 2020 | | 4180 | 14 | 298.57 |
| 22 | Javan Rae Noyes | So | Mid-Buchanan | 2018 | | 4035 | 14 | 288.21 |
| 23 | Garren Vroman | Sr | Fayette | 2021 | | 3350 | 13 | 257.69 |