| Rank | Total | Student | Grade | School | Year | |
| 1 | 17:14.22 | Taylor Werner | Sr | Ste. Genevieve | 2015 | |
| 2 | 17:31.30 | Taylor Werner | So | Ste. Genevieve | 2013 | |
| 3 | 17:38.29 | Hannah Long | Sr | Eureka | 2014 | |
| 4 | 17:46.72 | Anna Marie West | Sr | Lafayette (Wildwood) | 2015 | |
| 5 | 17:46.82 | Hannah Long | Jr | Eureka | 2013 | |
| 6 | 17:51.40 | Merideth Snow | Sr | Eureka | 2005 | |
| 7 | 17:56.00 | Emily P. Sisson | Sr | Parkway Central | 2009 | |
| 8 | 17:57.00 | Emily P. Sisson | Jr | Parkway Central | 2008 | |
| 9 | 17:59.64 | Samantha Nicole Nightingale | Jr | Blue Springs South | 2010 | |
| 10 | 17:59.90 | Jamie Elizabeth Kempfer | Sr | Festus | 2013 | |
| 11 | 18:01.56 | Sarah Jane Nicholson | Sr | Lafayette (Wildwood) | 2015 | |
| 12 | 18:02.26 | Mikayla Reed | Jr | Washington | 2016 | |
| 13 | 18:05.51 | Samantha Nicole Nightingale | Sr | Blue Springs South | 2011 | |
| 14 | 18:06.91 | Hannah Long | So | Eureka | 2012 | |
| 15 | 18:07.18 | Victoria Ann Findley | So | Blue Springs South | 2015 | |
| 16 | 18:09.01 | Sophia Racetta | Sr | Nerinx Hall | 2014 | |
| 17 | 18:09.34 | Victoria Ann Findley | Sr | Blue Springs South | 2017 | |
| 18 | 18:09.49 | Jessica Robin Jackson | Sr | Neosho | 2010 | |
| 19 | 18:13.14 | Hannah Pierson | Jr | Marquette | 2014 | |
| 20 | 18:15.45 | Grace Ellen Klausen | Sr | Blue Springs South | 2014 | |
| 21 | 18:16.80 | Megan Thompson | Sr | Hazelwood Central | 1989 | |
| 22 | 18:19.88 | Taylor Werner | Fr | Ste. Genevieve | 2012 | |
| 23 | 18:20.06 | Anna Marie West | Jr | Lafayette (Wildwood) | 2014 | |
| 24 | 18:20.20 | Jill Whitman | Sr | Cor Jesu Academy | 2013 | |
| 25 | 18:20.50 | Susan Bliss | Sr | Francis Howell | 1987 | |