| Rank | Total | Student | School | Opponent | Date | |
| 1 | 49 | | Rosary | Central Visual and Performing Arts | 2/24/1998 | at Soldan |
| 2 | 47 | | Chadwick | Lutie | 12/15/2011 | |
| 3 | 36 | | New Bloomfield | Osage | 11/30/1987 | |
| 3 | 36 | | Warren County | Lutheran St. Charles | 1/16/1994 | |
| 5 | 34 | | Clopton | Louisiana | 1/23/2006 | |
| 6 | 33 | | Putnam County | Mercer | 1/12/1998 | |
| 7 | 32 | | St. James | Arcadia Valley | 12/26/2001 | |
| 7 | 32 | | Chadwick | Niangua | 1/8/2002 | |
| 7 | 32 | | Chadwick | Galena | 2/15/2002 | |
| 7 | 32 | | Skyline | Richmond | 12/20/2002 | |
| 7 | 32 | | Stanberry | Tarkio | 2/19/2002 | |
| 12 | 30 | | Meadville | Bevier | 1/10/2023 | 30 assists |
| 12 | 30 | | Meadville | Northwestern (Mendon) | 11/30/2023 | |
| 12 | 30 | | Meadville | Novinger | 2/2/2024 | |
| 15 | 28 | | Southern Boone | Community | 1/30/1987 | |
| 15 | 28 | | Twin Rivers | Caruthersville | 1/26/2021 | |
| 15 | 28 | | Meadville | Tina-Avalon | 1/29/2024 | |
| 18 | 26 | | Meadville | Tina-Avalon | 1/30/2023 | 26 assists |
| 19 | 25 | | Meadville | La Plata | 1/13/2023 | 25 assists |
| 19 | 25 | | Meadville | Northwestern (Mendon) | 1/20/2023 | 25 assists |
| 19 | 25 | | Meadville | Winston | 12/14/2023 | |
| 19 | 25 | | Meadville | Bucklin | 1/23/2024 | |
| 23 | 24 | | Scott County Central | Gainesville | 3/1/1982 | |
| 23 | 24 | | Meadville | Glasgow | 11/17/2023 | |
| 23 | 24 | | Meadville | Brashear | 12/8/2023 | |
| 26 | 23 | | Springfield Catholic | North Platte | 3/1/1989 | |
| 26 | 23 | | Grundy County | Winston | 12/17/2019 | |
| 26 | 23 | | Meadville | Green City | 1/17/2023 | 23 assists |
| 26 | 23 | | Meadville | Linn County | 12/12/2023 | |
| 26 | 23 | | Meadville | Hale | 2/1/2024 | |
| 26 | 23 | | Meadville | Grundy County | 2/15/2024 | |
| 26 | 23 | | Meadville | Northwestern (Mendon) | 2/21/2024 | |
| 33 | 22 | | Marionville | Eskridge | 3/1/1991 | |
| 33 | 22 | | St. Joseph's Academy | Kickapoo | 3/1/1994 | |
| 33 | 22 | | Meadville | Bucklin | 2/10/2023 | 22 assists |
| 33 | 22 | | Meadville | Brunswick | 2/23/2024 | |
| 33 | 22 | | Meadville | Green City | 2/26/2024 | |
| 38 | 21 | | Rich Hill | Lutheran (Kansas City) | 3/1/1988 | |
| 38 | 21 | | Salisbury | Springfield Catholic | 3/1/1989 | |
| 38 | 21 | | Meadville | Scott County Central | 3/1/1995 | |
| 38 | 21 | | Meadville | Bevier | 1/31/2024 | |
| 38 | 21 | | Meadville | Green City | 2/12/2024 | |
| 43 | 20 | | Meadville | Bishop LeBlond | 2/5/2024 | |
| 43 | 20 | | Meadville | La Plata | 2/7/2024 | |