| Rank | Total | Student | School | Opponent | Date | |
| 1 | 137 | | Russellville | Eldon | 3/5/1970 | 137-8 |
| 1 | 137 | | Hickman Mills High School | Ruskin | 1/16/1986 | 137-32 |
| 3 | 133 | | Kelly | Twin Rivers | 1/19/1978 | 133-14 |
| 4 | 130 | | Scott County Central | Oran | 12/16/1991 | 130-15 |
| 5 | 127 | | Rosary | Central Visual and Performing Arts | 2/24/1998 | 127-8 |
| 6 | 122 | | Scott County Central | Woodland | 2/11/1993 | 122-22 |
| 7 | 121 | | Bronaugh | Metz | 12/15/1950 | 121-55 |
| 7 | 121 | | Hardin-Central | Breckenridge | 2/18/1981 | 121-101 |
| 9 | 120 | | Elsberry | St. Mary's (St. Louis) | 1/9/1984 | 120-27 |
| 9 | 120 | | Rich Hill | Sheldon | 2/19/1988 | 120-50 |
| 11 | 106 | | Meadville | Hale | 1/23/2023 | 106 points |
| 12 | 103 | | Meadville | Bevier | 1/10/2023 | 103 points |
| 13 | 98 | | Twin Rivers | Caruthersville | 1/26/2021 | |
| 14 | 97 | | Scott County Central | Gainesville | 3/1/1982 | |
| 14 | 97 | | Southern Boone | Bunceton | 11/21/1983 | |
| 16 | 93 | | Southern Boone | Versailles | 12/30/2016 | |
| 17 | 91 | | Holden | Monroe City | 3/1/1988 | |
| 17 | 91 | | Southern Boone | Versailles | 1/15/2019 | |
| 19 | 90 | | Scott County Central | New Bloomfield | 3/1/1991 | |
| 20 | 89 | | Southern Boone | Fayette | 2/23/1996 | |
| 21 | 88 | | Scott County Central | Rich Hill | 3/1/1992 | |
| 21 | 88 | | Southern Boone | St. Clair | 1/10/2022 | |
| 23 | 87 | | Southern Boone | Liberty-Christian | 2/21/2022 | |
| 24 | 86 | | Marshfield | Perryville | 3/1/1991 | |
| 24 | 86 | | Meadville | Scott County Central | 3/1/1995 | |