| Rank | Student | Grade | School | Year | | STL | G | PerG |
| 1 | Danielle Freeman | Sr | Soldan International Studies | 1988-1989 | | 234 | 24 | 9.75 |
| 2 | Kim Woodruff | Sr | St. James | 1996-1997 | | 257 | 27 | 9.52 |
| 3 | Kenna Rae Walker | So | New Bloomfield | 1996-1997 | | 236 | 27 | 8.74 |
| 4 | Madison Carvajal | Fr | Meadville | 2022-2023 | | 249 | 29 | 8.59 |
| 5 | Kenna Rea Walker | Sr | New Bloomfield | 1988-1989 | | 258 | 31 | 8.32 |
| 6 | Iesia Sutton | Jr | Berkeley High School | 2001-2002 | | 196 | 24 | 8.17 |
| 7 | Madison Carvajal | So | Meadville | 2023-2024 | | 234 | 29 | 8.07 |
| 8 | Jada Bentley | Sr | Beaumont | 2006-2007 | | 173 | 22 | 7.86 |
| 9 | Nikki Ilg | Sr | St. John the Baptist | 2001-2002 | | 151 | 20 | 7.55 |
| 10 | Jordann Plummer | So | Cardinal Ritter | 2002-2003 | | 179 | 24 | 7.46 |
| 11 | LeAnn Peckham | Sr | Sarcoxie | 1983-1984 | | 200 | 27 | 7.41 |
| 12 | Kim Woodruff | Jr | St. James | 1995-1996 | | 210 | 29 | 7.24 |
| 13 | Donna Simon | Sr | Duchesne | 1995-1996 | | 200 | 28 | 7.14 |
| 14 | Destiny Dowell | Sr | Tipton | 2015-2016 | | 189 | 27 | 7.00 |
| 15 | Carrie Dickinson | Sr | DeSoto | 1991-1992 | | 194 | 28 | 6.93 |
| 16 | Jade Berry | Sr | Delta | 2024-2025 | | 196 | 29 | 6.76 |
| 17 | Carlie Sanders | Sr | Hillsboro | 2017-2018 | | 175 | 26 | 6.73 |
| 18 | Kim Woodruff | So | St. James | 1994-1995 | | 208 | 32 | 6.50 |
| 19 | Korrie Holcer | Sr | Meadville | 2023-2024 | | 187 | 29 | 6.45 |
| 20 | Crystal Smith | Jr | Jasper | 2023-2024 | | 165 | 26 | 6.35 |
| 21 | Lacy Stokes | Fr | Mt. Vernon | 2017-2018 | | 183 | 30 | 6.10 |
| 22 | Carlie Sanders | Jr | Hillsboro | 2016-2017 | | 158 | 26 | 6.08 |
| 23 | Lacy Stokes | Sr | Mt. Vernon | 2020-2021 | | 194 | 32 | 6.06 |
| 24 | Maddie Ayers | Fr | South Iron | 2019-2020 | | 171 | 30 | 5.70 |
| 25 | Keylie Beane | Sr | Lathrop | 2023-2024 | | 155 | 28 | 5.54 |
| 26 | Crystal Smith | So | Jasper | 2022-2023 | | 132 | 24 | 5.50 |
| 27 | Victoria Nauman | Sr | Mound City | 2018-2019 | | 152 | 28 | 5.43 |
| 28 | Jade Berry | Jr | Delta | 2023-2024 | | 154 | 30 | 5.13 |
| 29 | Korrie Holcer | Jr | Meadville | 2022-2023 | | 152 | 30 | 5.07 |
| 30 | Destiny Dowell | Jr | Tipton | 2014-2015 | | 150 | 30 | 5.00 |
| 31 | Lilyan Carr | So | Spokane | 2024-2025 | | 133 | 27 | 4.93 |
| 32 | Kelsi McQuinn | Sr | Jefferson (Conception) | 2016-2017 | | 147 | 30 | 4.90 |
| 33 | Paige Carvajal | Jr | Meadville | 2022-2023 | | 142 | 30 | 4.73 |
| 34 | Clara Williams | So | Tipton | 2023-2024 | | 148 | 32 | 4.63 |