| Rank | Student | Grade | School | Year | | G | Total |
| 1 | Melissa Grider | Jr | Marion C. Early | 1989-1990 | | 29 | 452 |
| 2 | Sierra Michaelis | Sr | Mercer | 2012-2013 | | 31 | 441 |
| 3 | Joyce Amsmeyer | Sr | Southern Boone | 1965-1966 | | 25 | 404 |
| 4 | Lisa Ellis | Sr | Elsberry | 1983-1984 | | 27 | 397 |
| 5 | Leah Cauble | Sr | Oran | 2018-2019 | | 29 | 393 |
| 6 | Shyla Tucker | Jr | Fredericktown | 1988-1989 | | 27 | 388 |
| 7 | Teresa Jackson | Sr | Monroe City | 1988-1989 | | 28 | 384 |
| 8 | Sierra Michaelis | Jr | Mercer | 2011-2012 | | 29 | 378 |
| 9 | Leah Cauble | So | Oran | 2016-2017 | | 32 | 377 |
| 10 | Lisa Ellis | Jr | Elsberry | 1982-1983 | | 28 | 376 |
| 11 | Leah Cauble | Jr | Oran | 2017-2018 | | 29 | 373 |
| 12 | Angie Bonner | Sr | Southwest (St. Louis) High School | 1980-1981 | | 29 | 368 |