| Rank | Total | Student | School | Opponent | Date | |
| 1 | 71 | | Dixon | Stoutland | 12/2/1968 | |
| 2 | 67 | | Bevier | Ethel | 1/24/1967 | |
| 3 | 65 | | William Chrisman | King City | 12/26/1972 | |
| 4 | 63 | | Dixon | Stoutland | 2/11/1969 | |
| 4 | 63 | | Marquand-Zion | University (Cape Girardeau) | 1/26/1986 | |
| 6 | 62 | | Dixon | Richland | 11/8/1968 | |
| 6 | 62 | | Christian Brothers (St. Joseph) High School | Faucett | 12/29/1969 | |
| 6 | 62 | | Steelville | Kingston | 11/25/2003 | |
| 9 | 61 | | Sacred Heart | Climax Springs | 11/3/1972 | |
| 9 | 61 | | Memorial (Joplin) High School | Carl Junction | 2/28/1978 | |
| 9 | 61 | | Bernie | Cooter | 11/30/1992 | |
| 12 | 49 | | Macks Creek | | 12/6/2019 | vs Tuscumbia |
| 13 | 46 | | Southeast | Palmyra | 3/1/1973 | |
| 14 | 44 | | Scott County Central | Pattonsburg | 3/1/1990 | |
| 14 | 44 | | Scott County Central | Pilot Grove | 3/1/2010 | |
| 16 | 43 | | Scott County Central | King City | 3/1/1987 | |
| 17 | 42 | | Scott County Central | Harrisburg | 3/1/1979 | |
| 17 | 42 | | Scott County Central | Wellsville | 3/1/1980 | |