| Rank | Total | Student | School | Opponent | Date | |
| 1 | 249 | | Bernie | North Pemiscot | 11/22/1991 | 147 - 102 |
| 2 | 243 | | Central High School (St. Louis) | Vashon | 2/1/1980 | 126 - 117 |
| 3 | 225 | | Central High School (St. Louis) | Sumner | 1/14/1981 | 130 - 95 |
| 4 | 224 | | Beaumont | Sumner | 1/22/1987 | 114 - 110 |
| 5 | 223 | | Central (St. Louis) | Visual & Performing Arts | 1/10/1980 | 166 - 57 |
| 5 | 223 | | Eugene | Versailles | 11/24/2020 | |
| 5 | 223 | | Versailles | Eugene | 11/24/2020 | |
| 8 | 222 | | Greenville | Lesterville | 12/17/1963 | 120 - 102 |
| 8 | 222 | | Fatima | Southern Boone County | 12/16/1971 | 113 - 109 |
| 10 | 220 | | Greenville | Twin Rivers | 1/12/1965 | 113 - 107 |
| 10 | 220 | | Sumner | Southwest (St. Louis) | 2/27/1981 | 117 - 103 |
| 10 | 220 | | Cabool | Dora | 2/21/1995 | 120 - 100 |
| 10 | 220 | | Wheatland | Hermitage | 2/23/1995 | 120 - 100 |
| 14 | 217 | | Clarkton | Holcomb | 1/22/2019 | 113 - 104 |
| 15 | 207 | | Sheldon | Hermitage | 2/9/2019 | |