| Rank | School | Opponent | Date | | Q | Pts |
| 1 | Harrisburg | Madison | 1/9/1971 | | 4 | 56 |
| 2 | Clearwater | Zalma | 1/15/1980 | | 1 | 52 |
| 2 | Marquand-Zion | University High (Cape Girardeau) | 1/26/1986 | | 3 | 52 |
| 4 | Richland (Essex) | Bernie | 11/8/1977 | | 1 | 51 |
| 5 | Dixon | Richland | 11/8/1968 | | 2 | 50 |
| 5 | Scott County Central | Cooter | 12/6/2007 | (at Oran) | 1 | 50 |
| 7 | Bogard High School | Stet | 1/24/1964 | | 3 | 49 |
| 7 | Tuscumbia | Bland | 2/9/1974 | | 4 | 49 |
| 9 | Bevier | Ethel | 1/24/1967 | | 3 | 48 |
| 10 | Madison | Renick | 2/25/1953 | | 4 | 47 |
| 10 | Dixon | Stoutland | 12/2/1968 | | 3 | 47 |
| 10 | Naylor | Winona | 2/25/1980 | | 2 | 47 |
| 13 | Glendale | Oak Park | 12/3/2015 | | 1 | 41 |
| 14 | Glendale | West Plains | 1/31/2017 | | 1 | 40 |
| 14 | Higbee | Bevier | 11/22/2022 | | 3 | 40 |
| 14 | Greenwood | Jefferson City | 1/22/2022 | | 4 | 40 |
| 17 | Chaminade College Prep | Webster Groves | 1/1/2018 | | 4 | 38 |
| 17 | Scott City | St. Pius X (Festus) | 12/10/2024 | | 1 | 38 |
| 19 | Riverview Gardens | Raytown South | 3/1/1992 | | 4 | 37 |
| 19 | Riverview Gardens | Raytown South | 1/1/1992 | | 4 | 37 |
| 19 | Branson | Harrison Ark | 12/10/2024 | | 3 | 37 |
| 19 | Chaffee | Zalma | 2/10/2026 | | 1 | 37 |
| 23 | Eugene | Calvary Lutheran | 2/2/2021 | | 3 | 36 |
| 24 | Holcomb | | 1/8/2019 | | 4 | 35 |
| 24 | Vashon | Potosi | 3/21/2025 | | 1 | 35 |
| 26 | Jefferson City | DeSoto | 3/1/1993 | | 4 | 34 |
| 26 | Jefferson City | DeSoto | 1/1/1993 | | 4 | 34 |
| 26 | O'Hara | Notre Dame (Cape Girardeau) | 3/1/2005 | | 4 | 34 |
| 26 | O'Hara | Notre Dame (Cape Girardeau) | 1/1/2005 | | 4 | 34 |
| 26 | Scott County Central | Newtown-Harris | 3/1/2009 | | 1 | 34 |
| 26 | Scott County Central | Newtown-Harris | 3/1/2009 | | 1 | 34 |
| 26 | Scott County Central | Newtown-Harris | 1/1/2009 | | 1 | 34 |
| 26 | Vashon | Potosi | 3/21/2025 | | 3 | 34 |
| 26 | Smithton | La Monte | 1/24/2025 | | 3 | 34 |
| 35 | Licking | St. Pius X (Kansas City) | 3/1/1989 | | 4 | 32 |
| 35 | Scott County Central | Pattonsburg | 3/1/1990 | | 2 | 32 |
| 35 | Jennings | St. Francis Borgia | 3/1/1993 | | 4 | 32 |
| 35 | Green City | Scott County Central | 3/1/1993 | | 4 | 32 |
| 35 | St. Pius X (Festus) | Crystal City | 1/3/2024 | | 2 | 32 |