| Rank | Total | Student | School | Opponent | Date | |
| 1 | 28 | Jerome V Jones | Miller Career Academy | Gateway | 1/9/2009 | |
| 1 | 28 | Cortez Dobbins | Malden | Senath-Hornersville | 1/13/2015 | |
| 3 | 27 | Jeff Girdner | Mercer | Braymer | 1/30/2003 | |
| 3 | 27 | Clay Gayman | Nevada | Center | 2/17/2017 | |
| 3 | 27 | Aminu Mohammed | Greenwood | Billings | 12/10/2018 | |
| 6 | 25 | Bill Shanks | Willow Springs | Houston | 2/15/1966 | At Meadville |
| 6 | 25 | Norman Turner | Wheatland | Bolivar | 1/27/1967 | |
| 6 | 25 | Blake Short | McDonald County | Mountain Home, AR | 12/2/2002 | At. Republic |
| 6 | 25 | Cory Via | Harrisburg | Laquey | 3/19/2009 | |
| 6 | 25 | Cory Via | Harrisburg | Laquey | 3/1/2009 | |
| 6 | 25 | Clayton R Schieber | Jefferson (Conception) | Southeast | 1/26/2012 | |
| 12 | 24 | Joe Davis | Kelly | Richland (Essex) | 2/17/1970 | |
| 12 | 24 | Jim Rolfes | Prep South High School (St. Louis) | Valley Park | 1/14/1977 | |
| 12 | 24 | Larry Howlett | St. John's (Kansas City) | Pembroke Hill | 12/3/1977 | |
| 12 | 24 | Ethan Boyer | East Carter | Couch | 1/13/2012 | |
| 16 | 23 | Samuel Bunting | Campbell | Winona | 2/14/2022 | |
| 17 | 20 | Lamont Frazier | Charleston | McCluer South-Berkeley | 3/1/1989 | |
| 17 | 20 | Nathan Bilyeu | Ozark | Paseo Academy | 3/1/2003 | |
| 19 | 19 | Ed Stoll | Raytown South | Sumner | 3/1/1972 | |
| 19 | 19 | Carter Trumbore | Butler | Archie | 1/27/2022 | |
| 19 | 19 | Derek Rockett | Higbee | Braymer | 1/20/2023 | |
| 22 | 18 | Torrence G Watson | Whitfield | Hogan Prep Academy Charter | 3/1/2017 | |
| 22 | 18 | Kyle Renkoski | Pierce City | Aurora | 12/11/2020 | |
| 24 | 17 | Jerry Brockmiller | Highland | Hannibal | 12/21/1976 | |
| 24 | 17 | Anthony Grote | Silex | Silex | 1/30/2020 | |
| 24 | 17 | Carter Trumbore | Butler | Leeton | 2/3/2023 | |
| 24 | 17 | Carter Trumbore | Butler | Warsaw | 2/10/2023 | |
| 28 | 16 | Jacob Shoemaker | Oran | Crane | 3/1/2017 | |
| 28 | 16 | Aminu Mohammed | Greenwood | Glendale | 12/29/2018 | |
| 28 | 16 | Carter Trumbore | Butler | Knob Noster | 12/3/2022 | |
| 31 | 15 | Jevon Crudup | Raytown South | Vashon | 3/1/1990 | |
| 31 | 15 | Bert Presley | Diamond | Monroe City | 3/1/1995 | |
| 31 | 15 | Mark Dannenmueller | Scott City | | 2/3/2004 | vs. Bell City |
| 31 | 15 | Jacob Akin | St. Elizabeth | Bell City | 3/1/2005 | |
| 31 | 15 | Carter Trumbore | Butler | Skyline | 1/20/2023 | |
| 31 | 15 | Carter Trumbore | Butler | Holden | 2/20/2023 | |
| 31 | 15 | Carter Trumbore | Butler | Versailles | 1/18/2024 | |