| Rank | Total | Student | School | Opponent | Date | |
| 1 | 42 | George (Luke) Wilson | Elsberry | O'Fallon | 2/24/1953 | |
| 2 | 37 | J. D. Boyer | Winona | Freemont | 2/8/1955 | |
| 3 | 34 | Lionel Smith | Madison | Renick | 2/25/1953 | |
| 4 | 32 | Charles R. Miller | Ellisnore (East Carter) | Naylor | 1/28/1953 | |
| 4 | 32 | Steve Greisinger | Albany | Martinsville | 2/18/1985 | |
| 6 | 31 | Leroy Boyer | New Bloomfield | Chamois | 2/1/1955 | |
| 6 | 31 | Percy Wells | Central (St. Louis) | Soldan | 1/20/1971 | |
| 8 | 30 | Leonard Boehmer | Assumption High School (O'Fallon) | Brussells, IL | 2/22/1959 | |
| 8 | 30 | Jackson Lloyd | Winona | Dora | 11/14/1969 | |
| 10 | 29 | Scott Wolfe | Kemper | Higbee | 2/16/1973 | |
| 11 | 20 | Greg Wakefield | Winona | | 1/17/1995 | |
| 11 | 20 | Tim Scheer | New Haven | Bishop Hogan Jr. H. | 3/1/1997 | |
| 11 | 20 | Hunter Lane | Macks Creek | | 12/6/2019 | vs Tuscumbia |
| 11 | 20 | Carter Trumbore | Butler | Versailles | 1/18/2024 | |
| 15 | 18 | Larry Wilgus | La Plata | Southwest (Mooresville) | 3/1/1959 | |
| 15 | 18 | Lawrence Butler | Glasgow | Smithton | 3/1/1974 | |
| 15 | 18 | Kent Russell | Nixa | Lilbourn | 3/1/1978 | |
| 15 | 18 | Anthony Timmons | Scott County Central | Clopton | 3/1/1983 | |
| 15 | 18 | Aminu Mohammed | Greenwood | College Heights Christian | 12/13/2018 | |
| 15 | 18 | Aminu Mohammed | Greenwood | Fordland | 12/13/2018 | |
| 15 | 18 | Aminu Mohammed | Greenwood | Versailles | 12/5/2019 | |
| 22 | 17 | Marty Hardin | Hallsville | Penney | 3/1/1981 | |
| 22 | 17 | Mike Lawson | Pattonsburg | Malta Bend | 3/1/1990 | |
| 22 | 17 | Greg Wakefield | Winona | | 1/21/1995 | |
| 25 | 16 | Otto Porter Sr. | Scott County Central | Drexel | 3/1/1976 | |
| 25 | 16 | Ray Pugh | Malden | Waynesville | 3/1/1985 | |
| 25 | 16 | Greg Wakefield | Winona | | 12/20/1994 | |
| 25 | 16 | Joseph Cole Register | Macks Creek | | 12/6/2019 | vs. Tuscumbia |
| 25 | 16 | Aminu Mohammed | Greenwood | Weaubleau | 12/19/2019 | |
| 25 | 16 | Aminu Mohammed | Greenwood | Milan | 2/8/2020 | |
| 25 | 16 | Aminu Mohammed | Greenwood | Clever | 2/6/2020 | |
| 32 | 14 | Carter Trumbore | Butler | Adrian | 1/5/2023 | |