| Rank | Student | School | Years | | AST | Sets | Total |
| 1 | Sarah Mueller | Santa Fe | 1994-1997 | | 2515 | 191 | 13.17 |
| 2 | Carley Nicholson | St. Pius X (Festus) | 2014-2017 | | 3722 | 328 | 11.35 |
| 3 | Natalie Emro | Lafayette (Wildwood) | 2005-2006 | | 1496 | 143 | 10.46 |
| 4 | Erin McClanahan | Cor Jesu Academy | 1999-2001 | | 1954 | 188 | 10.39 |
| 5 | Sydney Brooke Golden | Nixa | 2018-2021 | | 3920 | 378 | 10.37 |
| 6 | Sydney Brooke Golden | Nixa | 2018-2020 | | 2839 | 277 | 10.25 |
| 7 | Hannah Joyce | Pleasant Hill | 2018-2020 | | 2505 | 253 | 9.90 |
| 8 | Logan Ryann Jones | Carl Junction | 2019-2022 | | 3503 | 355 | 9.87 |
| 9 | Miya Carnes | Carl Junction | 2022-2023 | | 1173 | 120 | 9.78 |
| 10 | Macey Browers | Arcadia Valley | 2015-2018 | | 3030 | 310 | 9.77 |
| 11 | Jenny Orf | Lafayette (Wildwood) | 2000-2003 | | 2834 | 290 | 9.77 |
| 12 | Olivia Lotz | Timberland | 2014-2017 | | 2759 | 292 | 9.45 |
| 13 | Sophie Whitesell | Lockwood | 2005-2008 | | 2801 | 302 | 9.27 |
| 14 | Alexa Ethridge | Lee's Summit North | 2005 | | 2973 | 321 | 9.26 |
| 15 | Maggie Scott | Lafayette (Wildwood) | 2011-2013 | | 2279 | 249 | 9.15 |
| 16 | Danika Wattenbarger | St. Joseph Christian | 2020-2023 | | 3289 | 362 | 9.09 |
| 16 | Danika Wattenbarger | St. Joseph Christian | 2020-2023 | | 3289 | 362 | 9.09 |
| 18 | Rielly Dobbs | Nixa | 2012-2015 | | 1945 | 216 | 9.00 |
| 19 | Alli Mitchell | Miller | 2018-2021 | | 3085 | 344 | 8.97 |
| 20 | Alaina Nicole Saunders | Belton | 2019-2022 | | 2972 | 336 | 8.85 |
| 21 | Amy Lindhorst | Oak Park | 2009-2012 | | 2633 | 298 | 8.84 |
| 22 | Malerie Lynn Sharp | Gideon | 2018-2021 | | 2529 | 290 | 8.72 |
| 23 | Shannon Ayer | Notre Dame de Sion | 1999-2002 | | 2728 | 314 | 8.69 |
| 24 | Katie Hyneman | Oak Park | 2005-2006 | | 1235 | 147 | 8.40 |
| 25 | Cali Bailey | Mid-Buchanan | 2017-2019 | | 1787 | 217 | 8.24 |
| 26 | Abby Chadwell | Strafford | 2019-2022 | | 3099 | 377 | 8.22 |
| 27 | Gracie Hicks | Lesterville | 2019-2022 | | 3139 | 382 | 8.22 |
| 28 | Emma Klein | East Buchanan | 2018-2021 | | 2439 | 300 | 8.13 |
| 29 | Hannah Nicole Vaughn | Poplar Bluff | 2015-2017 | | 1809 | 224 | 8.08 |
| 30 | Paige Alyssa Siebert | Jefferson (Festus) | 2019-2022 | | 2767 | 345 | 8.02 |
| 31 | Kylie Clark | East Buchanan | 2020-2023 | | 2004 | 254 | 7.89 |
| 32 | Taryn Nash | Truman | 2006-2009 | | 2425 | 309 | 7.85 |
| 33 | Erin Moore | Bernie | 1992-1995 | | 2366 | 307 | 7.71 |
| 34 | Lexie Malam | Houston | 2003-2006 | | 1623 | 217 | 7.48 |
| 35 | Bethanie Nicole Funderburk | Nixa | 2006-2009 | 3 Years | 1206 | 163 | 7.40 |
| 36 | Kenna O'Riley | Bishop LeBlond | 2016-2019 | | 2260 | 312 | 7.24 |
| 37 | Payton Woodrum | Mt. Vernon | 2012-2015 | | 2015 | 284 | 7.10 |
| 37 | Payton Woodrum | Mt. Vernon | 2012-2020 | | 2015 | 284 | 7.10 |
| 39 | Hallie Tucker | Bolivar | 2018-2020 | | 1646 | 236 | 6.97 |
| 40 | Kylie Aiko Hunter | Stockton | 2019-2023 | | 2409 | 347 | 6.94 |
| 41 | Kendra N Sater | Ozark | 2012-2015 | | 2501 | 364 | 6.87 |
| 42 | Bailey Myers | Lesterville | 2014-2017 | | 2002 | 292 | 6.86 |
| 43 | Gracie Fish | Jefferson (Festus) | 2016-2018 | | 1135 | 167 | 6.80 |
| 44 | Kira Phipps | Lawson | 2020-2022 | | 1743 | 259 | 6.73 |
| 44 | Kira Phipps | Lawson | 2020-2022 | | 1743 | 259 | 6.73 |
| 46 | Tedi Thoreson | El Dorado Springs | 1999-2002 | | 1913 | 293 | 6.53 |
| 47 | Ashley Hydorn | Oak Park | 1999-2002 | | 1955 | 302 | 6.47 |
| 48 | Abigail Cole | Licking | 2016-2019 | | 1844 | 291 | 6.34 |
| 49 | Madeline Yahnig | Midway | 2015-2018 | | 1784 | 283 | 6.30 |
| 50 | Lacy Stokes | Mt. Vernon | 2017-2020 | | 1928 | 317 | 6.08 |
| 50 | Lacy Stokes | Mt. Vernon | 2017-2020 | | 1928 | 317 | 6.08 |
| 52 | Jessie Humbird | Midway | 2017-2020 | | 1221 | 207 | 5.90 |
| 53 | Lillie May Anne Ricketts | Miller | 2019-2022 | | 943 | 165 | 5.72 |
| 54 | Lauren Hyde | Mid-Buchanan | 2013-2016 | | 1436 | 275 | 5.22 |
| 55 | Emily Powell | Midway | 2018-2022 | | 1406 | 287 | 4.90 |
| 56 | Kylie Taylor | Licking | 2018-2021 | | 743 | 320 | 2.32 |