| Rank | Student | School | Years | | K | Sets | AVG |
| 1 | Tessa Jones | O'Hara | 2000-2003 | | 1908 | 311 | 6.14 |
| 2 | Katie Panhorst | St. Charles | 1993-1995 | | 957 | 158 | 6.06 |
| 3 | Kristin Folkl | St. Joseph's Academy | 1990-1993 | | 1819 | 306 | 5.94 |
| 4 | Taylor Cook | Lesterville | 2008-2011 | | 1484 | 266 | 5.58 |
| 5 | Reese Gray | Lesterville | 2019-2022 | | 2121 | 382 | 5.55 |
| 6 | Emma Siron | Sacred Heart | 2019-2022 | | 1737 | 326 | 5.33 |
| 7 | Maddie DeMent | Arcadia Valley | 2017-2020 | | 1537 | 296 | 5.19 |
| 8 | Jamie Roszell | East Newton | 1995-1998 | | 1303 | 251 | 5.19 |
| 9 | Christi Myers | Raytown South | 1995-1998 | | 1399 | 274 | 5.11 |
| 10 | Marissa Hundelt | Orchard Farm | 2006-2009 | | 1165 | 230 | 5.07 |
| 11 | Kaitlyn M. Creek | Stockton | 2016-2019 | | 1265 | 256 | 4.94 |
| 12 | Mikayla Bonnell | Licking | 2015-2017 | | 1108 | 231 | 4.80 |
| 13 | Tera Reberry | Pleasant Hill | 2017-2020 | | 1180 | 247 | 4.78 |
| 14 | Summer Kenney | Stockton | 2019-2023 | Career Kills | 1646 | 347 | 4.74 |
| 15 | Julie Williams | St. Charles | 1992-1994 | | 765 | 164 | 4.66 |
| 16 | Mallory Polk | Lesterville | 2017-2020 | | 1574 | 338 | 4.66 |
| 17 | Lauren Standlee | Thomas Jefferson Independent | 1997-2000 | | 1208 | 263 | 4.59 |
| 18 | Autumn Craft | Verona | 1995-1998 | | 1401 | 310 | 4.52 |
| 19 | Rebekah Wedick | Willow Springs | 1996-1999 | | 1123 | 253 | 4.44 |
| 20 | Kara Schilli | Valle Catholic | 2001-2004 | | 1190 | 271 | 4.39 |
| 21 | Marianne Elizab Beal | Lee's Summit North | 2006-2009 | | 1330 | 303 | 4.39 |
| 22 | Aubrey Cheffey | Nixa | 2012-2015 | | 1168 | 269 | 4.34 |
| 23 | Kaitlyn Belk | Bunker | 2019-2022 | | 1374 | 323 | 4.25 |
| 24 | Cameron Layne Dake | Mt. Vernon | 2012-2015 | | 1190 | 284 | 4.19 |
| 24 | Cameron Layne Dake | Mt. Vernon | 2012-2015 | | 1190 | 284 | 4.19 |
| 26 | Amelia Flynn | Timberland | 2014-2017 | | 1045 | 250 | 4.18 |
| 27 | Nevaeh Malawey | Winona | 2019-2022 | | 1532 | 372 | 4.12 |
| 28 | Maya Watkins | East Buchanan | 2019-2022 | | 1197 | 308 | 3.89 |
| 29 | Morgan N. Beal | Lee's Summit North | 2009-2012 | | 1239 | 319 | 3.88 |
| 30 | Salma Lewis | Carl Junction | 2017-2020 | Career kills | 1227 | 327 | 3.75 |
| 31 | Baylee Russ | Midway | 2018-2022 | | 1243 | 333 | 3.73 |
| 32 | Lily Johnson | Lafayette (Wildwood) | 2010-2013 | | 974 | 264 | 3.69 |
| 33 | Kylie Scott | Carl Junction | 2020-2023 | | 1173 | 325 | 3.61 |
| 34 | Ryenne Olivia Gepford | Butler | 2017-2020 | | 1000 | 281 | 3.56 |
| 35 | Lisa Downey | Lafayette (Wildwood) | 1998-2000 | | 1030 | 295 | 3.49 |
| 36 | Anna Harrold | Lawson | 2019-2022 | | 1138 | 335 | 3.40 |
| 37 | Catherine Elizabeth Woolf | North Point | 2020-2023 | | 1161 | 359 | 3.23 |
| 38 | Jaycee Theo Fixsen | Nixa | 2018-2021 | | 1191 | 369 | 3.23 |
| 39 | Makenna Irvin | Midway | 2014-2017 | | 877 | 273 | 3.21 |
| 40 | Hilah Fish | Jefferson (Festus) | 2013-2016 | 3 years Varsity | 580 | 181 | 3.20 |
| 41 | Alyxandra Marie Gepford | Butler | 2010-2013 | | 901 | 282 | 3.20 |
| 42 | Regan Michele Peltier | Nixa | 2008-2011 | | 980 | 313 | 3.13 |
| 43 | Kirstyn Michele Loyd | Jefferson (Festus) | 2019-2022 | | 1084 | 349 | 3.11 |
| 44 | Hannah Medlock | Licking | 2020-2022 | | 715 | 232 | 3.08 |
| 45 | Emma Allyn Breier | Jefferson (Festus) | 2019-2022 | | 1042 | 345 | 3.02 |
| 46 | Emma Allyn Breier | Jefferson (Festus) | 2019-2022 | | 1036 | 345 | 3.00 |
| 47 | Emberlynn M Kingsley | Miller | 2019-2022 | | 936 | 329 | 2.84 |
| 48 | Haylie Marie Schnake | Miller | 2019-2022 | | 1031 | 368 | 2.80 |
| 49 | Cora Roweton | Bolivar | 2019-2022 | | 1032 | 372 | 2.77 |
| 50 | Ava Kay Roth | Jefferson (Festus) | 2019-2022 | | 889 | 349 | 2.55 |
| 51 | Mikayla Bonnell | Licking | 2015-2017 | | 569 | 231 | 2.46 |
| 52 | Holly Caylor | East Buchanan | 2020-2023 | | 832 | 347 | 2.40 |
| 53 | Emily Smith | Licking | 2010-2013 | | 328 | 143 | 2.29 |
| 54 | Abigail Sullins | Licking | 2019-2022 | | 578 | 265 | 2.18 |
| 55 | Bailie Osborne | Licking | 2011-2014 | | 477 | 220 | 2.17 |
| 56 | Kamryn Barnes | Licking | 2017-2020 | | 467 | 262 | 1.78 |
| 57 | Abagail Moncrief | Licking | 2016-2019 | | 478 | 279 | 1.71 |
| 58 | Abigail Cole | Licking | 2016-2019 | | 420 | 291 | 1.44 |