| Rank | Student | Grade | School | Year | | G | SB |
| 1 | Jayden Hasam | So | University Academy Charter | 2021 | | 27 | 64 |
| 2 | Chris Coy | Sr | Benton | 2024 | | 37 | 61 |
| 3 | Jared Alverson | Jr | Exeter | 2017 | | 23 | 58 |
| 4 | Cody Burkhardt | Sr | Hermitage | 2009 | | 21 | 56 |
| 5 | James Gowin | Sr | Hermitage | 2008 | | 24 | 55 |
| 6 | Porter McCarthy | Fr | Benton | 2024 | | 37 | 54 |
| 7 | Kasen Gaston | Sr | Summersville | 2024 | | 19 | 52 |
| 8 | David Miller | Sr | Belle | 1983 | | 16 | 51 |
| 8 | Garyn Hall | Sr | Houston | 2022 | | 26 | 51 |
| 10 | Garrett Mork | So | Bismarck | 2021 | | 22 | 50 |
| 10 | Lucas Robert Efken | Sr | Bayless | 2022 | | 23 | 50 |
| 10 | Jayden Hassan | Jr | University Academy Charter | 2022 | | 25 | 50 |
| 10 | Carson Nicholas Schmidt | Sr | Benton | 2024 | | 36 | 50 |
| 14 | Jayden Hasam | Fr | University Academy Charter | 2020 | | 19 | 49 |
| 15 | Jeff Morris | Sr | Diamond | 2006 | | 25 | 48 |
| 15 | Aaron Garner | Jr | Pierce City | 2018 | | 24 | 48 |
| 17 | Kimo Concepcion | Jr | Stoutland | 1999 | | 17 | 47 |
| 17 | Aiden S Heberlie | Jr | Valle Catholic | 2020 | | 33 | 47 |
| 17 | Garrett Mork | Sr | Bismarck | 2023 | | 23 | 47 |
| 20 | Nick Moore | Sr | Wright City | 2022 | | 23 | 45 |
| 20 | Nick Moore | Sr | Wright City | 2022 | | 23 | 45 |
| 22 | Kimo Concepcion | So | Stoutland | 1998 | | 16 | 44 |
| 23 | Kyler Fanning | Sr | Moberly | 2025 | | 35 | 43 |
| 23 | | Sr | Moberly | 2025 | | 35 | 43 |
| 25 | Nathan Dunn | Sr | Marshfield | 2000 | | 29 | 42 |
| 25 | Danny Maier | Sr | New Franklin | 2004 | | 21 | 42 |
| 25 | Colin Gowin | So | Hermitage | 2010 | | 21 | 42 |
| 25 | Garrett Mork | Jr | Bismarck | 2022 | | 20 | 42 |
| 29 | Grant Douglas Dotson | Sr | Jackson | 2022 | | 41 | 41 |
| 30 | Rick Huskey | Sr | Herculaneum | 1997 | | 25 | 40 |
| 30 | Ryan Smith | Sr | Hermitage | 2008 | | 24 | 40 |
| 30 | Garyn Hall | Jr | Houston | 2021 | | 23 | 40 |
| 33 | Ryker Zimmerman | Jr | Southern Boone | 2022 | | 35 | 38 |
| 34 | Kaden Matthew Kinsler | So | Elsberry | 2020 | | 25 | 37 |
| 34 | Tyler Baer | So | Tipton | 2021 | | 21 | 37 |
| 34 | Caden Reece Bogenpohl | Sr | Jackson | 2022 | | 41 | 37 |
| 34 | Tytus A Cissell | Sr | Francis Howell | 2023 | | 42 | 37 |
| 38 | Kaden Matthew Kinsler | Jr | Elsberry | 2021 | | 30 | 35 |
| 38 | Lucas Cashman | Fr | Tipton | 2021 | | 21 | 35 |
| 38 | | Sr | Southern Boone | 2023 | | 37 | 35 |
| 41 | Garyn Hall | So | Houston | 2020 | | 20 | 33 |
| 42 | Quinton Alexander Borders | Sr | Jackson | 2022 | | 41 | 31 |
| 42 | Cooper Phillip Rhodes | So | Jackson | 2022 | | 41 | 31 |
| 44 | Noah Bodenhausen | Jr | Savannah | 2018 | | 27 | 30 |
| 45 | Connor Earleywine | Jr | Jefferson City | 2020 | | 37 | 29 |
| 46 | Tyler Lutjen | Sr | Clinton | 2020 | | 26 | 28 |
| 46 | Truman Bodenhausen | Sr | Savannah | 2022 | | 33 | 28 |
| 46 | Zeke Jones | Sr | Summersville | 2023 | | 20 | 28 |
| 49 | Jackson Ramsey Wyatt | Sr | Jackson | 2022 | | 41 | 27 |
| 49 | Brady Nolen | Jr | Festus | 2023 | | 25 | 27 |
| 51 | Henley Allen Parker | Sr | Jackson | 2022 | | 41 | 25 |
| 52 | Danny Lee Venable | Sr | Houston | 2022 | | 26 | 24 |
| 52 | Andrew Hotop | Sr | St. Vincent | 2025 | | 22 | 24 |
| 54 | Gavin Jansen | Sr | Kelly | 2020 | | 28 | 23 |
| 54 | Gavin Jansen | Sr | Kelly | 2021 | | 25 | 23 |
| 54 | Landon James Watkins | Sr | Jackson | 2022 | | 41 | 23 |
| 57 | Aiden Kelly | Jr | Houston | 2022 | | 25 | 22 |
| 57 | Gavyn Briggs | Fr | Summersville | 2025 | | 16 | 22 |
| 59 | | Jr | Clinton | 2016 | | 22 | 21 |
| 59 | Trey Miller | Jr | Clinton | 2016 | | 22 | 21 |
| 59 | Kasen Gaston | Jr | Summersville | 2023 | | 20 | 21 |
| 59 | Quinton Whistler | Fr | St. Vincent | 2025 | | 23 | 21 |
| 63 | Zachary Kent Craig | Sr | Summersville | 2021 | | 14 | 20 |
| 63 | Augusta Stefen Unterreiner | Sr | St. Vincent | 2025 | | 22 | 20 |
| 65 | Zeke Jones | Jr | Summersville | 2022 | | 19 | 18 |
| 66 | Crockett Parham | Sr | Summersville | 2018 | | 17 | 16 |
| 67 | Clayton Shockley | Sr | Belle | 2023 | | 21 | 15 |