| Rank | Student | Grade | School | Year | | G | W |
| 1 | Kyle White | Jr | Christian Brothers College | 1976 | | 20 | 42 |
| 1 | Kayden Carter | Sr | Plattsburg | 2021 | | 37 | 42 |
| 3 | Kyler Fanning | Sr | Moberly | 2025 | | 35 | 41 |
| 4 | Wyatt Ducos | Sr | Crest Ridge | 2024 | | 25 | 39 |
| 5 | Cameron Chick | Sr | Hickman | 2017 | | 38 | 36 |
| 6 | Glen Verslues | So | Helias Catholic | 1987 | | 27 | 35 |
| 6 | Levi Matthew McKinnie | Sr | Chaffee | 2023 | | 29 | 35 |
| 8 | James Brock Steggall | Sr | Plattsburg | 2021 | | 38 | 34 |
| 9 | Jace Reynolds | Sr | Southern Boone | 2023 | | 37 | 33 |
| 9 | Wyatt William Miller | So | Wellington-Napoleon | 2025 | | 23 | 33 |
| 11 | John Cassmeyer | Sr | Helias Catholic | 1980 | | 26 | 32 |
| 11 | James Abel | Sr | West County | 2005 | | 22 | 32 |
| 11 | Will Young | Fr | Plato | 2007 | | 23 | 32 |
| 11 | Jack Welch | Sr | Bernie | 2010 | | 26 | 32 |
| 15 | Leon Davenport | Jr | Grandview | 1999 | | 20 | 31 |
| 15 | Shane Noel | Sr | Webb City | 2020 | | 32 | 31 |
| 15 | Thomas A Andert | Sr | Southern Boone | 2021 | | 36 | 31 |
| 18 | Sammy Taylor | Sr | Lilbourn | 1976 | | 24 | 30 |
| 18 | Ryan Hirsch | Sr | Parkway West | 1994 | | 25 | 30 |
| 18 | Mark Fisher | Sr | Central (Cape Girardeau) | 2000 | | 29 | 30 |
| 18 | Aaron Henry | Sr | Thayer | 2005 | | 26 | 30 |
| 22 | Ryan Perkins | Sr | Francis Howell | 2016 | | 40 | 29 |
| 22 | Gage Michael Singer | Sr | Aurora | 2018 | | 27 | 29 |
| 22 | Hunter Matthew Risch | Jr | Plattsburg | 2022 | | 34 | 29 |
| 25 | Jackson Lewis | Jr | Plattsburg | 2021 | | 38 | 28 |
| 25 | Aidan Cole | Sr | Liberty (Wentzville) | 2023 | | 36 | 28 |
| 27 | Jerrod Steger | Sr | Chaffee | 2007 | | 22 | 27 |
| 27 | Landon Tenkhoff | Sr | Chaffee | 2018 | | 28 | 27 |
| 27 | Sam Maddox | Sr | Francis Howell | 2020 | | 38 | 27 |
| 27 | Leo Humbert | Fr | Francis Howell | 2021 | | 42 | 27 |
| 31 | Cameron Michael Witt | Jr | Monett | 2014 | | 28 | 26 |
| 31 | Collin Murray | Sr | Iberia | 2017 | | 22 | 26 |
| 31 | David Clay Kemp | Jr | Hollister | 2020 | | 32 | 26 |
| 31 | Lucas Cashman | Fr | Tipton | 2021 | | 21 | 26 |
| 31 | Levi Matthew McKinnie | Jr | Chaffee | 2022 | | 31 | 26 |
| 36 | Peyton Braile | Sr | Liberty (Wentzville) | 2023 | | 37 | 25 |
| 37 | Nicholas Drew Roberts | Sr | Monett | 2012 | | 26 | 24 |
| 37 | Mathew Miller | Sr | Aurora | 2017 | | 32 | 24 |
| 39 | Grant Zeigenbein | Jr | Stoutland | 2018 | | 23 | 23 |
| 39 | Case Sanderson | Jr | Nevada | 2021 | | 24 | 23 |
| 39 | Zeke Jones | Sr | Summersville | 2023 | | 20 | 23 |
| 39 | Blake Henry | Sr | Belle | 2023 | | 23 | 23 |
| 43 | Jared Alverson | Jr | Exeter | 2017 | | 23 | 22 |
| 43 | Zach Craig | Jr | Summersville | 2020 | | 22 | 22 |
| 43 | Garrett Gehlert | So | Belle | 2023 | | 23 | 22 |
| 43 | Rylan Sutton | Jr | Ozark | 2025 | | 33 | 22 |
| 47 | James Brock Steggall | Jr | Plattsburg | 2020 | | 22 | 21 |
| 48 | Kasen Gaston | Sr | Summersville | 2023 | | 20 | 20 |
| 49 | Laydon Fields | Fr | Green City | 2018 | | 16 | 19 |
| 49 | Brett Norfleet | Jr | Francis Howell | 2021 | | 42 | 19 |
| 49 | Brysen Nepute | Jr | Francis Howell | 2021 | | 42 | 19 |
| 52 | Hunter Wulff | So | Belle | 2023 | | 23 | 18 |
| 53 | Clayton Shockley | Sr | Belle | 2023 | | 21 | 16 |
| 54 | Skylar William Wohlers | So | Osceola | 2022 | | 16 | 15 |
| 54 | Hank Stratman | So | Belle | 2023 | | 23 | 15 |
| 56 | Jaden Thacker | Sr | Winona | 2020 | | 17 | 14 |