| Rank | SO | Student | School | Opponent | Date | |
| 1 | 22 | Tyler Abma | Miller | Walnut Grove | 4/16/2007 | at Ash Grove |
| 2 | 21 | Doug Housewright | Steelville | Viburnum | 3/24/1970 | |
| 2 | 21 | Jim Rasnick | North County | St. Vincent | 4/2/1980 | |
| 4 | 20 | Kelly Hedgpeth | Clever | Ash Grove | 3/30/1967 | |
| 4 | 20 | Mike Brandt | Linn | Blair Oaks | 4/7/1988 | |
| 4 | 20 | Tony Endicott | Carl Junction | Seneca | 3/23/1998 | |
| 4 | 20 | Jon Barratt | Hillcrest | Nixa | 4/3/2003 | |
| 4 | 20 | Nathan Kelsey | Brashear | Canton | 4/4/2003 | |
| 4 | 20 | Tyler Hunt | Westran | Fayette | 4/21/2008 | |
| 4 | 20 | Austin Bentlage | Union | New Haven | 4/18/2012 | |
| 4 | 20 | Jarrett Pike | Southwest (Washburn) | | 9/7/2018 | |
| 4 | 20 | Nicholas Dale Bowers | Windsor | Tipton | 4/13/2021 | |
| 4 | 20 | Eli Brown | Saxony Lutheran | Bloomfield | 3/20/2021 | |
| 14 | 19 | Tyson Helsel | Mid-Buchanan | West Platte | 5/11/1998 | |
| 14 | 19 | Kyle McGirl | Eldon | Jamestown | 5/3/2002 | |
| 14 | 19 | Jacob Bunten | Palmyra | South Shelby | 5/6/2004 | |
| 14 | 19 | Chris Barratt | Hillcrest | Lebanon | 5/16/2006 | at Glendale |
| 14 | 19 | Josh White | Stoutland | Walnut Grove | 5/23/2007 | |
| 14 | 19 | Luke S Wozny | Carrollton | Odessa | 3/28/2014 | |
| 14 | 19 | Gavin Claud | Carrollton | Richmond | 3/24/2021 | |
| 14 | 19 | Bentley Boggs | Tuscumbia | Prairie Home | 9/29/2022 | |
| 14 | 19 | Lukas Barnes | Cooter | Risco | 5/16/2023 | |
| 14 | 19 | Bryce Manley | Delta (Deering) | Blytheville AR | 4/4/2024 | |
| 14 | 19 | Blake Williams | Bevier | Bucklin | 9/27/2024 | |
| 14 | 19 | Thomas Smith | University Academy Charter | Northeast (Kansas City) | 4/16/2026 | |
| 26 | 18 | Kelly Hedgpeth | Clever | Crane | 9/7/1966 | |
| 26 | 18 | Kelly Hedgpeth | Nixa | Forsyth | 3/29/1966 | no-hitter |
| 26 | 18 | Blake McFadden | Savannah | Marshall | 6/2/2012 | Class 3 |
| 26 | 18 | Cooper Wilken | Weaubleau | Fair Play | 4/19/2021 | |
| 26 | 18 | Bryce D Taylor | Northeast (Cairo) | Moberly | 4/19/2021 | |
| 26 | 18 | Bryce D Taylor | Northeast (Cairo) | Putnam County | 5/10/2021 | 6.2 IP |
| 26 | 18 | Corbin Joe Axtell | Grundy County | Cainsville | 4/26/2022 | |
| 26 | 18 | Levi Matthew McKinnie | Chaffee | Scott City | 5/3/2023 | |
| 26 | 18 | Caden Reece Bogenpohl | Jackson | Oakville | 5/18/2023 | |
| 26 | 18 | Gabriel James Berry | Otterville | Sacred Heart | 4/15/2025 | |
| 36 | 17 | Conner Wolf | Tipton | Northwest (Hughesville) | 4/27/2021 | |
| 36 | 17 | Samuel Peyton Hodges | East Prairie | Charleston | 4/27/2022 | |
| 36 | 17 | Gavin Mullins | Kingsville | Leeton | 5/15/2025 | |
| 39 | 16 | Tim Siegel | New Bloomfield | Southland | 6/1/1989 | Class 1A |
| 39 | 16 | David Anderson | Englewood Christian | Norwood | 6/1/2000 | Class 1A |
| 39 | 16 | Chris Mackey | Springfield Catholic | East Carter | 6/2/2004 | Class 2 |
| 39 | 16 | Scotty Boone | South Pemiscot | Blair Oaks | 6/1/2006 | Class 2 |
| 39 | 16 | Mike Grace | Parkway North | | 4/2/2005 | |
| 39 | 16 | Gage Michael Singer | Aurora | | 4/21/2018 | |
| 39 | 16 | Wyatt Baker Sparks | Aurora | | 4/2/2018 | |
| 39 | 16 | Cory Cantrell | Fair Play | Wheatland | 4/27/2021 | |
| 39 | 16 | Bryce D Taylor | Northeast (Cairo) | Salisbury | 5/3/2021 | 0 BB |
| 39 | 16 | Ethan Osborne | Southern Boone | Hallsville | 4/22/2021 | |
| 39 | 16 | Seth Benes | Liberty (Wentzville) | Ft. Zumwalt North | 4/19/2022 | |
| 39 | 16 | Josiah Golden | Lafayette County | Wellington-Napoleon | 4/13/2022 | |
| 39 | 16 | Ross Edward Peters | Kelly | East Carter | 4/29/2023 | |
| 52 | 15 | Frank Baumann | Central (STL) | Central (Cape Girardeau) | 5/29/1952 | |
| 52 | 15 | Jim Johnston | Normandy | McBride (STL) | 5/23/1953 | |
| 52 | 15 | Mike Yost | Valley Park | New Bloomfield | 6/1/1988 | Class 1A |
| 52 | 15 | Bob Keppel | DeSmet | Joplin | 6/2/2000 | Class 4A |
| 52 | 15 | Austin Erickson | Aurora | | 4/12/2018 | |
| 52 | 15 | Wyatt Baker Sparks | Aurora | | 4/19/2018 | |
| 52 | 15 | Wyatt Baker Sparks | Aurora | | 5/15/2018 | |
| 52 | 15 | Hayden Mathew Generaux | DeKalb | North Andrew | 4/27/2021 | |
| 52 | 15 | Samuel Peyton Hodges | East Prairie | Twin Rivers | 4/2/2022 | |
| 52 | 15 | Owen Casen Knight | East Prairie | Campbell | 4/18/2023 | |
| 52 | 15 | Noah Wade Johnson | East Prairie | Senath-Hornersville | 4/17/2025 | |
| 63 | 14 | Cole Keller | Grain Valley | Grain Valley | 6/4/2021 | |
| 63 | 14 | Clayton Shockley | Belle | Dixon | 5/14/2024 | |
| 63 | 14 | Clayton Shockley | Belle | Dixon | 3/21/2024 | |