| Rank | School | Year | | W | G | PerG |
| 1 | Walnut Grove | 2008 | | 151 | 21 | 7.190 |
| 2 | Lakeland | 1998 | | 154 | 22 | 7.000 |
| 3 | Plato | 2007 | | 153 | 23 | 6.652 |
| 4 | Hermitage | 2009 | | 139 | 21 | 6.619 |
| 5 | Lawson | 2007 | | 99 | 15 | 6.600 |
| 6 | Thayer | 2005 | | 178 | 27 | 6.593 |
| 7 | Green City | 2016 | | 72 | 11 | 6.545 |
| 8 | Bishop LeBlond | 1999 | | 140 | 22 | 6.364 |
| 9 | Christian Brothers College | 1976 | | 126 | 20 | 6.300 |
| 9 | Bevier | 2023 | | 63 | 10 | 6.300 |
| 9 | Bevier | 2023 | | 63 | 10 | 6.300 |
| 12 | Plattsburg | 2025 | | 207 | 33 | 6.273 |
| 13 | Scott City | 2025 | | 230 | 37 | 6.216 |
| 14 | Summit Christian Academy | 2012 | | 176 | 29 | 6.069 |
| 15 | Green City | 2018 | | 97 | 16 | 6.063 |
| 16 | Lawson | 2003 | | 118 | 20 | 5.900 |
| 17 | Plattsburg | 2021 | | 223 | 38 | 5.868 |
| 18 | Marion C. Early | 2020 | | 162 | 28 | 5.786 |
| 18 | Marion C. Early | 2020 | | 162 | 28 | 5.786 |
| 20 | Windsor | 2020 | | 133 | 24 | 5.542 |
| 21 | Plattsburg | 2022 | | 184 | 34 | 5.412 |
| 22 | Southern Boone | 2021 | | 189 | 36 | 5.250 |
| 23 | Monett | 2013 | | 136 | 26 | 5.231 |
| 23 | Monett | 2013 | | 136 | 26 | 5.231 |
| 25 | Webb City | 2020 | | 166 | 32 | 5.188 |
| 26 | Jackson | 2022 | | 212 | 41 | 5.171 |
| 27 | Hollister | 2020 | | 164 | 32 | 5.125 |
| 28 | Hickman | 2017 | | 193 | 38 | 5.079 |
| 29 | Southern Boone | 2020 | | 128 | 26 | 4.923 |
| 30 | Jackson | 2020 | | 151 | 31 | 4.871 |
| 31 | Kelly | 2020 | | 132 | 28 | 4.714 |
| 32 | Scott City | 2023 | | 155 | 33 | 4.697 |
| 33 | Southern Boone | 2022 | | 163 | 35 | 4.657 |
| 34 | Southern Boone | 2023 | | 172 | 37 | 4.649 |
| 35 | Green City | 2017 | | 87 | 19 | 4.579 |
| 36 | Tipton | 2022 | | 134 | 30 | 4.467 |
| 37 | Jackson | 2025 | | 151 | 34 | 4.441 |
| 38 | Aurora | 2017 | | 141 | 32 | 4.406 |
| 39 | Exeter | 2017 | | 100 | 23 | 4.348 |
| 40 | Liberty (Wentzville) | 2023 | | 157 | 37 | 4.243 |
| 41 | Parkway North | 2012 | | 144 | 34 | 4.235 |
| 42 | Osceola | 2024 | | 80 | 21 | 3.810 |
| 43 | Jackson | 2024 | | 141 | 38 | 3.711 |
| 44 | Southern Boone | 2025 | | 122 | 33 | 3.697 |
| 45 | Southern Boone | 2018 | | 94 | 26 | 3.615 |
| 46 | Francis Howell | 2021 | | 150 | 42 | 3.571 |
| 47 | Southern Boone | 2024 | | 109 | 33 | 3.303 |
| 48 | Ft. Zumwalt West | 2017 | | 154 | 2014 | .076 |