| Rank | Student | School | Years | | ER | IP | Total |
| 1 | Ryan Edwards | Francis Howell | 1993-1995 | | 11 | 118 | 0.653 |
| 2 | Ethan Osborne | Southern Boone | 2017-2020 | | 17 | 154.1 | 0.771 |
| 3 | Andrew Huckaby | Conway | 2013-2016 | | 12 | 108 | 0.778 |
| 4 | Mark Baker | Central (Park Hills) | 1981-1982 | | 14 | 120.1 | 0.814 |
| 5 | Sammy Taylor | Lilbourn | 1975-1977 | | 10 | 84 | 0.833 |
| 6 | Kevin Houston | Liberty | 1974-1977 | | 18 | 132 | 0.955 |
| 7 | Corey Spain | Monett | 2015-2018 | | 25 | 177 | 0.989 |
| 8 | Logan Agan | Vienna | 2015-2018 | | 30 | 211 | 0.995 |
| 9 | Gavin Claud | Carrollton | 2018-2020 | | 24 | 160.2 | 1.046 |
| 10 | Derrick Morris | Walnut Grove | 2005-2008 | | 34 | 217 | 1.097 |
| 11 | Hunter Dame | Conway | 2013-2016 | | 39 | 242.2 | 1.125 |
| 12 | Jacob Turner | Westminster Christian Academy | 2006-2009 | | 28 | 171.1 | 1.144 |
| 13 | Mark Steighorst | Hillsboro | 1968-1971 | | 31 | 185 | 1.173 |
| 14 | Dan Archer | Central (Park Hills) | 1989-1991 | | 24 | 138.2 | 1.212 |
| 15 | Jacob Daniel Weirich | Jefferson City | 2014-2017 | | 36 | 207 | 1.217 |
| 16 | Jerry Vansell | Blue Springs | 1987-1990 | | 15 | 86 | 1.221 |
| 17 | Calem Nutting | Webb City | 2013-2015 | | 22 | 123.2 | 1.245 |
| 18 | Carter Salter | Southern Boone | 2020-2022 | | 23 | 123 | 1.309 |
| 19 | Wyatt Baker Sparks | Aurora | 2014-2017 | | 43 | 228.1 | 1.318 |
| 20 | Mark Harvey | Westran | 1994-1997 | | 55 | 288 | 1.337 |
| 21 | Travis Henke | Blair Oaks | 2004-2007 | | 37 | 181 | 1.431 |
| 22 | Matt Gilmer | Central (New Madrid County) | 1990-1993 | | 47 | 222 | 1.482 |
| 23 | | Aurora | 2014-2017 | | 43 | 22.1 | 13.478 |