| Rank | Student | School | Years | | G | IP |
| 1 | Mathias Miller | Conway | 1999-2002 | | 53 | 320 |
| 2 | Mark Harvey | Westran | 1994-1997 | | 56 | 288 |
| 3 | Bo Kennedy | Central (Park Hills) | 1983-1986 | | 42 | 281.2 |
| 4 | Jay Marshall | John F. Kennedy High School | 1998-2001 | | 48 | 277 |
| 5 | Lucas Ryan Cashman | Tipton | 2021-2024 | | 54 | 271.1 |
| 6 | Matt Frevert | Hallsville | 2002-2005 | | 58 | 257 |
| 7 | Tyler Burgess | Webb City | 2007-2010 | | 39 | 248 |
| 8 | Hunter Dame | Conway | 2013-2016 | | 49 | 242.2 |
| 9 | Nick Green | Lawson | 1995-1998 | | 50 | 241.2 |
| 10 | Cody Burkhardt | Hermitage | 2006-2009 | | 86 | 235.1 |
| 11 | Mike Dambach | Lilbourn | 1967-1970 | | 42 | 234 |
| 12 | Sam LeCure | Helias Catholic | 1999-2002 | | 45 | 232 |
| 13 | Jay Bollinger | Grandview | 1994-1997 | | 46 | 231.1 |
| 14 | Levi Matthew McKinnie | Chaffee | 2020-2023 | | 59 | 231 |
| 15 | Matt Gilmer | Central (New Madrid County) | 1990-1993 | | 46 | 222 |