| Rank | Student | School | Years | | G | HBP |
| 1 | Tucker Dement | Ellington | 2018-2021 | | 135 | 58 |
| 2 | Jacob Talbot | Plato | 2004-2006 | | 67 | 45 |
| 2 | Justin Perkins | Francis Howell | 2013-2016 | | 75 | 45 |
| 4 | William Geary | Valley Park | 2021-2024 | | 104 | 44 |
| 5 | Bricker Berry | Macks Creek | 2009-2013 | | 68 | 40 |
| 6 | Wyatt Francis Moran | Plattsburg | 2020-2022 | | 93 | 39 |
| 7 | Jared Gage | Summit Christian Academy | 2009-2012 | | | 38 |
| 7 | Camden McLallen | Plattsburg | 2022-2025 | | 110 | 38 |
| 9 | Brett Gollhofer | Monett | 2013-2016 | | 82 | 36 |
| 9 | Carter Karotka | Southern Boone | 2018-2021 | | 88 | 36 |
| 11 | Colton McAnally | Grandview (Hillsboro) | 2015-2018 | | 69 | 35 |
| 12 | Cody Burkhardt | Hermitage | 2006-2009 | | 85 | 33 |
| 13 | Brent Maggard | Sparta | 2002-2005 | | 128 | 32 |
| 14 | Tyler Baer | Tipton | 2020-2023 | | 102 | 31 |
| 15 | Kyle McCallister | Monett | 2012-2015 | | 100 | 30 |
| 15 | Jesse Linton | Macks Creek | 2013-2017 | | 81 | 30 |
| 17 | Craig Penley | Plato | 2002-2005 | | 82 | 28 |
| 18 | Lucas Cashman | Tipton | 2021-2024 | | 109 | 27 |
| 18 | Bryce Bradford | Bayless | 2022-2025 | | 76 | 27 |
| 20 | Justin Jackson | Hickman | 2003-2005 | | 69 | 25 |
| 21 | LIndell Ray Harmon | Southern Boone | 2003-2006 | | 56 | 22 |
| 22 | Jesse Auten | Lakeland | 1999-20002 | | 93 | 21 |
| 22 | Nolan Sissom | Ft. Zumwalt West | 2022-2025 | | 149 | 21 |
| 24 | Andy Oliver | Fatima | 1994-1997 | | 70 | 20 |
| 24 | John Watson | Christian Brothers College | 2000-2002 | | 80 | 20 |
| 24 | Kris Irwin | Plato | 2002-2005 | | 82 | 20 |
| 24 | Mike Macke | Ft. Zumwalt South | 2007-2009 | | 69 | 20 |
| 24 | Ronnie Ray | Clearwater | 2007-2010 | | 75 | 20 |