| Rank | Student | School | Year | | ER | IP | G | Total |
| 1 | | Bishop LeBlond | 2004 | | 3 | 191.2 | 28 | 0.110 |
| 2 | | Palmyra | 2008 | | 5 | 200 | 26 | 0.175 |
| 3 | | Palmyra | 2009 | | 4 | 159 | 25 | 0.176 |
| 4 | | Santa Fe | 1999 | + spring season | 3 | 90 | 16 | 0.233 |
| 5 | | Palmyra | 1997 | | 7 | 180 | 27 | 0.272 |
| 6 | | Webb City | 2008 | | 6 | 147 | 33 | 0.286 |
| 7 | | Bevier | 2005 | | 7 | 154 | 26 | 0.318 |
| 7 | | Putnam County | 1989 | | 6 | 132 | 22 | 0.318 |
| 9 | | Palmyra | 2006 | | 9 | 180 | 27 | 0.350 |
| 10 | | John F. Kennedy High School | 2009 | | 8 | 158 | 24 | 0.354 |