| Rank | Total | Student | School | Opponent | Date | |
| 1 | 28 | | Dexter | Bloomfield | 3/22/2016 | |
| 2 | 26 | | Webb City | Belton | 9/26/2020 | |
| 2 | 26 | | Chillicothe | Savannah | 9/25/2021 | |
| 4 | 25 | | Central (New Madrid County) | Blytheville (Ark.) | 4/2/2003 | |
| 5 | 24 | | Eureka | Dixon | 10/4/1996 | (at Sullivan) |
| 5 | 24 | | Lathrop | Stewartsville | 9/12/2015 | |
| 5 | 24 | | Blue Springs South | Blue Springs South | 9/12/2022 | @ Staley |
| 8 | 23 | | Kirksville | Warrenton | 10/13/2010 | |
| 8 | 23 | | Holt | Sullivan | 8/30/2012 | |
| 8 | 23 | | North Platte | Mid-Buchanan | 9/19/2013 | |
| 8 | 23 | | Seckman | | 8/29/2014 | |
| 8 | 23 | | Lindbergh | | 9/5/2018 | Pattonville |
| 8 | 23 | | Webb City | Oak Park | 9/18/2020 | |
| 8 | 23 | | Chillicothe | Penney | 9/27/2021 | |
| 15 | 22 | | North Harrison | Tri-County | 9/10/1992 | |
| 15 | 22 | | Glendale | West Plains | 10/11/2002 | |
| 15 | 22 | | Seckman | Kelly A. Burlison | 10/2/2010 | |
| 15 | 22 | | St. Charles | McCluer | 8/29/2016 | |
| 15 | 22 | | Kelly | Chaffee | 9/9/2017 | |
| 15 | 22 | | Lindbergh | | 10/8/2018 | Kirkwood |
| 21 | 21 | | Community | Montgomery County | 9/20/1997 | |
| 21 | 21 | | Halfway | Fair Play | 9/12/2002 | (at Nevada) |
| 21 | 21 | | Centralia | Monroe City | 9/16/2013 | |
| 21 | 21 | | North Platte | Plattsburg | 9/23/2014 | |
| 21 | 21 | | Chillicothe | Lafayette (St. Joseph) | 9/7/2021 | |
| 21 | 21 | | North Point | Orchard Farm | 9/5/2023 | |
| 21 | 21 | | Highland | South Shelby | 10/3/2023 | |
| 21 | 21 | | Kingsville | Windsor | 4/5/2024 | |
| 29 | 20 | | Russellville | Eugene | 10/12/2020 | |
| 29 | 20 | | Chillicothe | Princeton | 9/25/2021 | |
| 29 | 20 | | Dixon | Climax Springs | 9/15/2022 | 5 inning Game |
| 32 | 19 | | Kelly | | 9/14/2019 | |
| 32 | 19 | | Webb City | Neosho | 9/29/2020 | |
| 32 | 19 | | Chillicothe | Lawson | 9/3/2020 | |
| 32 | 19 | | Fatima | Chillicothe | 10/29/2022 | |
| 36 | 18 | | Fatima | | 10/10/2014 | Class 2 |
| 37 | 17 | | Kelly | | 10/7/2019 | |
| 37 | 17 | | Russellville | Harrisburg | 9/28/2020 | |
| 37 | 17 | | Kelly | Twin Rivers | 9/22/2020 | |
| 37 | 17 | | Chillicothe | South Harrison | 9/11/2021 | |
| 37 | 17 | | Chillicothe | Kirksville | 9/11/2021 | |
| 37 | 17 | | Chillicothe | Fatima | 10/29/2022 | |
| 37 | 17 | | Mt. Vernon | Mt. Vernon | 5/22/2023 | |
| 37 | 17 | | Highland | Westminster Christian Academy | 9/2/2023 | |
| 37 | 17 | | Highland | Putnam County | 9/23/2023 | |
| 46 | 16 | | Chillicothe | Benton | 10/13/2020 | |
| 46 | 16 | | Highland | Palmyra | 9/25/2023 | |
| 48 | 15 | | Lee's Summit West | Parkway South | 10/29/2021 | |
| 48 | 15 | | Chillicothe | Maryville | 9/21/2021 | |
| 48 | 15 | | Chillicothe | Oak Grove | 9/25/2021 | |
| 48 | 15 | | Chillicothe | Maryville | 10/12/2021 | |
| 48 | 15 | | Chillicothe | Fatima | 10/29/2022 | |
| 48 | 15 | | Chillicothe | Fatima | 10/29/2022 | |
| 54 | 14 | | Lee's Summit | | 1/1/2013 | Class 4 |
| 54 | 14 | | Warrenton | | 1/1/2015 | Class 3 |
| 54 | 14 | | Chillicothe | Tina-Avalon | 9/8/2021 | |
| 54 | 14 | | Chillicothe | Highland | 9/11/2021 | |
| 54 | 14 | | Chillicothe | Holden | 10/20/2021 | |
| 59 | 11 | | St. Elizabeth | | 1/1/2002 | Class 1 |
| 59 | 11 | | Van Buren | | 1/1/2016 | Class 1 |