| Rank | Student | Grade | School | Year | | G | SB |
| 1 | Kaiden Weisbrod | Sr | Jackson | 2023 | | 38 | 85 |
| 2 | Taylor Akers | Sr | Kickapoo | 2022 | | 35 | 72 |
| 3 | Macie Botsch | Sr | Bernie | 2024 | Spring 2025 | 36 | 68 |
| 4 | Blair Pleimling | Jr | Bernie | 2024 | Spring 2025 | 36 | 67 |
| 5 | Stafanie Standley | Jr | Lamar | 2000 | | 24 | 65 |
| 5 | Laura Katherine Johnson | Jr | Central (New Madrid County) | 2024 | | 20 | 65 |
| 7 | Macie Botsch | Jr | Bernie | 2024 | | 34 | 63 |
| 8 | Chelsea King | Sr | Strafford | 2006 | | 28 | 56 |
| 8 | Kristin Austin | | Southern Boone | 2007 | | 25 | 56 |
| 8 | Molly Seabaugh | Jr | Advance | 2008 | | 16 | 56 |
| 8 | Bailey Burns | So | Puxico | 2016 | | 22 | 56 |
| 12 | Stefanie Standley | Sr | Lamar | 2001 | | 25 | 54 |
| 13 | Marissa Lewis | Sr | Metro | 2006 | | 26 | 52 |
| 13 | Bailey Burns | Fr | Puxico | 2015 | | 21 | 52 |
| 13 | Keera E Rothweiler | So | Highland | 2024 | | 33 | 52 |
| 13 | Keera E Rothweiler | Jr | Highland | 2025 | | 31 | 52 |
| 17 | Susan Reed | Sr | Eldon | 2001 | | 22 | 51 |
| 17 | Kelli Koehler | Sr | Weaubleau | 2002 | | 24 | 51 |
| 17 | Katy Roweton | Jr | Bolivar | 2007 | | 27 | 51 |
| 17 | Bailey Burns | Sr | Puxico | 2018 | | 21 | 51 |
| 17 | Katia Alezandria Todd | Jr | Hartville | 2023 | | 29 | 51 |
| 22 | Piper Schoemehl | Sr | Bernie | 2021 | | 29 | 50 |
| 23 | Julie Silver | Sr | Parkway Central | 2005 | | 26 | 49 |
| 23 | Maddie Guevara | Jr | Washington | 2022 | | 38 | 49 |
| 25 | Christen Belcher | Jr | Notre Dame de Sion | 2002 | | 26 | 48 |
| 25 | Sydney Miller | Sr | Willow Springs | 2018 | | 26 | 48 |
| 27 | Mykaela Arellanes | Jr | Holt | 2013 | | 28 | 47 |
| 27 | Katelin Ann Kurima | Sr | Monett | 2017 | | 32 | 47 |
| 29 | Laura Katherine Johnson | So | Central (New Madrid County) | 2023 | | 22 | 46 |
| 29 | Laura Katherine Johnson | So | Central (New Madrid County) | 2023 | | 22 | 46 |
| 31 | Abigail Posten | So | Crocker | 2017 | | 26 | 44 |
| 31 | Kiera Daniel | Jr | Warrenton | 2023 | | 28 | 44 |
| 33 | Ragan Blinzler | Sr | Pierce City | 2017 | | 25 | 43 |
| 33 | Emma Bolden | Fr | Bayless | 2023 | | 18 | 43 |
| 33 | Marissa Kohler | Sr | Bayless | 2023 | | 18 | 43 |
| 33 | Emma Elmore | Sr | Malden | 2023 | | 31 | 43 |
| 37 | Kenna Wise | Jr | Clever | 2020 | | 24 | 42 |
| 37 | Emma Elmore | Sr | Malden | 2023 | | 31 | 42 |
| 37 | Emma Elmore | Sr | Malden | 2023 | | 31 | 42 |
| 40 | Abigail Rickermann | Sr | Festus | 2019 | | 29 | 41 |
| 41 | Katie Shuffler | So | Malden | 2018 | | 26 | 40 |
| 41 | Piper Schoemehl | Jr | Bernie | 2020 | | 24 | 40 |
| 41 | Elizabeth Reed | Jr | Washington | 2022 | | 38 | 40 |
| 41 | Chloe Reed | Jr | Lutheran St. Charles | 2023 | | 28 | 40 |
| 41 | Ashlyn Claire Snodgrass | Sr | Benton | 2023 | | 23 | 40 |
| 46 | Olivia Jo Pfeifer | Sr | Hannibal | 2017 | | 21 | 39 |
| 46 | Abigail Rickermann | So | Festus | 2017 | | 27 | 39 |
| 46 | Centauri Todd | Sr | Hartville | 2021 | | 26 | 39 |
| 49 | Kaesha George | Jr | Monett | 2018 | | 32 | 38 |
| 49 | Jayli Johnson | Sr | College Heights Christian | 2022 | | 25 | 38 |
| 51 | Carissa Jean Martin | Jr | DeKalb | 2020 | | 16 | 37 |
| 52 | Emma Gail Cook | Sr | Hartville | 2022 | | 31 | 36 |
| 52 | Lexi Hunter | Jr | South Harrison | 2024 | | 34 | 36 |
| 54 | Macie Rae Fisher | So | Canton | 2021 | | 24 | 35 |
| 55 | Kelby Robinson | Jr | Holt | 2018 | | 28 | 34 |
| 56 | McKenna McCoy | Sr | Sullivan | 2016 | | 33 | 33 |
| 56 | Kiley Louise Thomas | So | Odessa | 2023 | | 30 | 33 |
| 58 | McKenna McCoy | Jr | Sullivan | 2015 | | 29 | 32 |
| 58 | Bailey Burns | Jr | Puxico | 2017 | | 16 | 32 |
| 58 | Reagan Grace Thomure | So | Sullivan | 2018 | | 33 | 32 |
| 61 | Kelby Robinson | Sr | Holt | 2019 | | 29 | 31 |
| 61 | Elle Smith | Sr | Blue Springs South | 2021 | | 35 | 31 |
| 61 | Laura Katherine Johnson | Fr | Central (New Madrid County) | 2022 | | 20 | 31 |
| 64 | Peyton Corrigan | Sr | Holden | 2018 | | 32 | 30 |
| 64 | Jayli Johnson | Jr | College Heights Christian | 2021 | | 23 | 30 |
| 64 | Macie Botsch | So | Bernie | 2022 | | 27 | 30 |
| 64 | Keera E Rothweiler | Fr | Highland | 2023 | | 30 | 30 |
| 64 | Kloee Williamson | Sr | McAuley Catholic | 2023 | | 22 | 30 |
| 69 | Alexa Higgins | Sr | Brashear | 2019 | | 20 | 29 |
| 69 | | So | Neelyville | 2022 | | 34 | 29 |
| 69 | Saige Bennett | Sr | South Harrison | 2023 | | 33 | 29 |
| 72 | Mykaela Arellanes | Sr | Holt | 2014 | | 32 | 28 |
| 72 | Magdalene Dooley | Jr | Christian | 2017 | | 22 | 28 |
| 72 | Kloee Williamson | So | McAuley Catholic | 2021 | | 23 | 28 |
| 72 | Kaetlyn Danley | So | Holcomb | 2021 | | 33 | 28 |
| 72 | Preslee Jo Sunderland | Jr | Fayette | 2022 | | 25 | 28 |
| 72 | Saige Bennett | Jr | South Harrison | 2022 | | 33 | 28 |
| 78 | Lilly Jones | Sr | Kelly | 2018 | | 24 | 26 |
| 78 | Sophia Luetticke | Jr | Chillicothe | 2020 | | 22 | 26 |
| 78 | Sophia Luetticke | Sr | Chillicothe | 2021 | | 35 | 26 |
| 78 | September Preslar | So | Neelyville | 2022 | | 31 | 26 |
| 82 | Kinsey J Fiedler | Sr | Lee's Summit North | 2020 | | 32 | 25 |
| 82 | Abbygail Lynn Powell | Jr | Bernie | 2022 | | 27 | 25 |
| 82 | Kloee Williamson | Jr | McAuley Catholic | 2022 | | 25 | 25 |
| 82 | Rylee Scarbrough | Sr | Willow Springs | 2022 | | 26 | 25 |
| 86 | Sierra Janette Snyder | So | Brashear | 2019 | | 20 | 24 |
| 86 | Kloee Williamson | Fr | McAuley Catholic | 2020 | | 18 | 24 |
| 86 | Hannah R Ritterbusch | So | Highland | 2024 | | 33 | 24 |
| 89 | Lexi Hunter | So | South Harrison | 2023 | | 33 | 23 |
| 90 | Chloe Madisyn Jones | So | Willow Springs | 2023 | | 30 | 21 |
| 90 | Adelynn Abell | Jr | Highland | 2024 | | 28 | 21 |
| 92 | Maleigh Lemings | So | Holcomb | 2021 | | 33 | 20 |