| Rank | Total | Student | School | Opponent | Date | |
| 1 | 18 | Brandie Roberts | Northeast (Cairo) | Keytesville | 9/3/2004 | |
| 1 | 18 | Whitney Mills | Couch | Alton | 8/23/2007 | |
| 1 | 18 | Sidney Copeland | Polo | Southwest (Livingston County) | 9/12/2013 | |
| 1 | 18 | Taylor Tiffany | Portageville | Twin Rivers | 9/8/2014 | |
| 1 | 18 | Izabelle Erickson | Reeds Spring | | 9/18/2018 | vs. Aurora |
| 6 | 17 | Jacquelyn Bishop | Kirksville | Hannibal | 8/24/2009 | |
| 6 | 17 | | Twin Rivers | Dexter | 3/25/2024 | Perfect Game |
| 8 | 16 | Tiffany Holman | Marion C. Early | Walnut Grove | 8/29/2002 | (22 BF) |
| 8 | 16 | Melissa Daniels | Northwestern (Mendon) | Southwest (Livingston County) | 9/2/2004 | |
| 8 | 16 | Alaina Jacobson | Crocker | Owensville | 10/2/2004 | (at Rolla) |
| 8 | 16 | Katelyn Tolle | Bevier | Meadville | 10/11/2009 | |
| 8 | 16 | Alessandra King | Christian | Principia | 10/8/2010 | |
| 8 | 16 | Abby Summers | West Platte | Mid-Buchanan | 9/30/2014 | |
| 8 | 16 | Sarah Handrahan | Jefferson (Festus) | Ste. Genevieve | 10/3/2016 | |
| 8 | 16 | Natalie Wilks | Sparta | Conway | 4/30/2021 | |
| 8 | 16 | Reese Elisabeth Plattner | Archie | Archie | 4/8/2021 | vs Jasper |
| 8 | 16 | Reese Elisabeth Plattner | Archie | Wellington-Napoleon | 5/10/2022 | |
| 18 | 12 | Hailey Presley | Marion C. Early | Pierce City | 4/14/2023 | |
| 18 | 12 | Hailey Presley | Marion C. Early | Greenfield | 4/14/2023 | |
| 20 | 11 | Lauren Fiene | Concordia | Lincoln | 4/23/2021 | |
| 20 | 11 | Karli Mae Johnson | Jackson | Owensville | 8/27/2021 | |
| 22 | 10 | Karli Mae Johnson | Jackson | Poplar Bluff | 9/22/2020 | |