| Rank | Total | Student | School | Opponent | Date | |
| 1 | 16 | - | Southern Boone | | 1/1/1981 | Class 1A-2A |
| 1 | 16 | - | Parkway Central | | 1/1/1981 | Class 3A-4A |
| 1 | 16 | - | Fatima | | 1/1/2014 | Class 2 |
| 4 | 13 | - | St. Elizabeth | | 1/1/1992 | Class 1 |
| 5 | 12 | - | Warrenton | | 1/1/2015 | Class 3 |
| 6 | 10 | - | Staley | | 1/1/2015 | Class 4 |
| 7 | 7 | Paige Eddington | Doniphan | Koshkonong | 5/5/2015 | |
| 8 | 6 | Dena Hecht | Ft. Zumwalt South | Normandy Collaborative | 9/6/1989 | |
| 8 | 6 | Autumn Walker | Central (New Madrid County) | Blytheville (Ark.) | 4/2/2003 | |
| 8 | 6 | Ryli Martin | Dixon | Climax Springs | 10/8/2020 | |
| 11 | 5 | Tressa Hughes | Dixon | Licking | 4/12/2018 | |
| 11 | 5 | Tayler McKinnon | Dixon | Licking | 4/12/2018 | |
| 11 | 5 | Maci Holtsclaw | Dixon | Climax Springs | 10/8/2020 | |
| 11 | 5 | Lexi Graves | Dixon | Climax Springs | 10/8/2020 | |
| 11 | 5 | Anna Rose Moore | Dixon | Climax Springs | 9/15/2022 | 5 inning Game |
| 11 | 5 | Kaetlyn Danley | Holcomb | Cooter | 4/13/2023 | |
| 11 | 5 | Maleigh Lemings | Holcomb | Naylor | 4/7/2023 | |
| 18 | 3 | Kirsten Dunn | Chillicothe | Fatima | 10/29/2022 | |